Protein Info for HP15_2969 in Marinobacter adhaerens HP15

Annotation: transcriptional regulator, MerR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 167 TIGR02047: Cd(II)/Pb(II)-responsive transcriptional regulator" amino acids 16 to 141 (126 residues), 156.1 bits, see alignment E=2.2e-50 PF00376: MerR" amino acids 17 to 54 (38 residues), 57 bits, see alignment 2e-19 PF13411: MerR_1" amino acids 17 to 83 (67 residues), 63.9 bits, see alignment E=1.8e-21 PF09278: MerR-DNA-bind" amino acids 59 to 122 (64 residues), 58.1 bits, see alignment E=1.7e-19

Best Hits

Swiss-Prot: 30% identical to HMRR2_RHIME: Heavy metal-dependent transcription regulator 2 (hmrR2) from Rhizobium meliloti (strain 1021)

KEGG orthology group: None (inferred from 70% identity to maq:Maqu_3108)

Predicted SEED Role

"Transcriptional regulator, MerR family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PNA0 at UniProt or InterPro

Protein Sequence (167 amino acids)

>HP15_2969 transcriptional regulator, MerR family (Marinobacter adhaerens HP15)
MIDSKQGFLNQAEIKVKIGELAKTTAIPVETIRYYEKIGLLPEPDRDNSGYRSYRTAHLD
RLLFIKRCRNLDMAQEEIRELIRLAEQPEADCSKVDALLAQHLVHVRERLKELASLEQTL
VNLQKACADGGTVRECGILGGLSSELESLEAENPDNHVPGTHGPGHS