Protein Info for PGA1_c30710 in Phaeobacter inhibens DSM 17395

Annotation: putative type I restriction-modification system, M subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 821 PF12161: HsdM_N" amino acids 8 to 149 (142 residues), 104.8 bits, see alignment E=5.9e-34 PF02384: N6_Mtase" amino acids 163 to 485 (323 residues), 323.6 bits, see alignment E=1.4e-100

Best Hits

KEGG orthology group: K03427, type I restriction enzyme M protein [EC: 2.1.1.72] (inferred from 71% identity to reh:H16_A0004)

Predicted SEED Role

"Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72)" in subsystem Restriction-Modification System (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F0I0 at UniProt or InterPro

Protein Sequence (821 amino acids)

>PGA1_c30710 putative type I restriction-modification system, M subunit (Phaeobacter inhibens DSM 17395)
MPLTLAQLERHLFSAADILRGKMDASEFKEYIFGMLFLKRCSDVFEQARLEVVQKRIASG
VAPEQAAEEAENKVWYGRSGTFWVPPQSRFGHLVDEAHENIGDKLNKALGGVESENIALE
GVLDHIDFTRKVGQSKISDQKLRQLINHFGEIRLRNEDFEFPDLLGAAYEYLIGEFADSA
GKKGGEFYTPRSVVRMMVRLLKPTLEHDIYDPCCGSGGMLIAAKDYIDEHGQDGRRANLF
GQENSGTVWSIAKMNMLLHGINSADLRNEDTLGEPQHVEDGELRRFDRILTNPPFSINWG
SKDKDRSGEYTWQPKFRERFFHEVPLGSKKADLMFLQHMLAVSRDGGMIATVMPHGVLFR
GGDEGKIRQKIIESDQVEAVIGLGPQLFYGTGIPACVIVLRQRVHHGANLVSGKPAERQG
KVLFINADREYFEGRAQNHLLPEHIEKIVTTFEEYRAIPGFSAIVDIDTLRENDFNLNIR
RYADNAPPPEPHDVRAHLVGGIPKAEVEAKADLFQSHGLNPMDLLTPRDENYLDFAASLT
AKSDLKPAIETNAGLTAREAEIKDSFNAWWGAHQDSIKSLAGAEDPAALITLRDELLSSF
SETLESLAMLDPFTVRGIIAQFWNQSRFDFLTLMARDTKGVVDAWRTSIVTALEDKGNKE
NPLDHKLVAFLMGDFVREIAELEARKAELDAQIKAATAKPEEGEEEEDEAEPVDEAQIKR
WKKELSEVKKTLKAKQAQFADEINAGVDGLSSEAAAELLLKILHDDMQRILTRYIAAQRG
QIVAAFENWWDKYRVTLTEIEGARAEATEKLAGFLKGLGYV