Protein Info for HP15_2936 in Marinobacter adhaerens HP15

Annotation: periplasmic sensor signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 168 to 190 (23 residues), see Phobius details PF14501: HATPase_c_5" amino acids 342 to 429 (88 residues), 25 bits, see alignment E=1.5e-09 PF02518: HATPase_c" amino acids 343 to 444 (102 residues), 62.9 bits, see alignment E=3.8e-21

Best Hits

KEGG orthology group: None (inferred from 62% identity to maq:Maqu_3059)

Predicted SEED Role

"Autolysis histidine kinase LytS" in subsystem Murein hydrolase regulation and cell death

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PN67 at UniProt or InterPro

Protein Sequence (445 amino acids)

>HP15_2936 periplasmic sensor signal transduction histidine kinase (Marinobacter adhaerens HP15)
MILSGLKRWGIATRMMVSALVLILLVLPVAGGLLAWNFREAVNTSFNNRLDSLLNVVIAG
VAYDVPNDALVLERQLGDPRFERVFSGWYWQATDGAERVITSRSLWDQRLPVVEGSQVVY
RQSAGPGGQTLRVAARTIQIPNLPDPLHVSVAADLTEVRAEVARFHRLLAVSLATLGVLL
LILIGLQIRWGLDPMRRVEKSLKSVEAGRQNSLATDLPEELARLARAINLVLERDQTLIE
RGRSAAGNLAHALKTPLSVLGTLSEQLPASQQQAFRAELQRLNAAVRHHLARASAAGPVG
LGRKTDLAEALTPVFAALEGLASRRGVQFEKNLGLAGPVRYEQQDIQEIVGNLLENAVNW
AEKRVELVLEQSPESLSIVVEDDGPGMSETQCAEALSRGARLDEERSGSGLGLSIVNDLV
RIYGGTLTLTRSGLGGLRVSVELPA