Protein Info for PGA1_c30120 in Phaeobacter inhibens DSM 17395

Annotation: cytochrome c oxidase subunit 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 transmembrane" amino acids 7 to 24 (18 residues), see Phobius details amino acids 30 to 48 (19 residues), see Phobius details amino acids 69 to 97 (29 residues), see Phobius details amino acids 117 to 139 (23 residues), see Phobius details amino acids 151 to 174 (24 residues), see Phobius details amino acids 188 to 208 (21 residues), see Phobius details amino acids 220 to 244 (25 residues), see Phobius details amino acids 264 to 286 (23 residues), see Phobius details amino acids 295 to 314 (20 residues), see Phobius details amino acids 332 to 354 (23 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 410 to 430 (21 residues), see Phobius details amino acids 441 to 461 (21 residues), see Phobius details amino acids 494 to 516 (23 residues), see Phobius details TIGR00780: cytochrome c oxidase, cbb3-type, subunit I" amino acids 67 to 530 (464 residues), 812.5 bits, see alignment E=6.4e-249 PF00115: COX1" amino acids 69 to 503 (435 residues), 373.2 bits, see alignment E=9.2e-116

Best Hits

Swiss-Prot: 76% identical to COX1_RHOCA: Cytochrome c oxidase subunit 1 (ctaD) from Rhodobacter capsulatus

KEGG orthology group: K00404, cb-type cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 89% identity to sit:TM1040_2545)

MetaCyc: 81% identical to cytochrome cbb3 oxidase subunit I (Rhodobacter capsulatus)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase subunit CcoN (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F0D1 at UniProt or InterPro

Protein Sequence (536 amino acids)

>PGA1_c30120 cytochrome c oxidase subunit 1 (Phaeobacter inhibens DSM 17395)
MSNYIKLIVLGLVTLFAMIATNYARDLAYQVHAIIIMIVAGGLFLYTLRHTDEPVIATGS
LQGEYFDSVVRAGVVATAFWGVVGFLVGVFIAFQLAFPVLNFEWAQGLANFGRLRPLHTS
AVIFAFGGNALIATSFYVVQRTSAARLWGGNLAWFVFWGYQLFIVLAATGYLFGSTQSKE
YAEPEWHVDLWLTIVWVAYLAVFLGTVIKRKEPHIYVANWFYLAFIVTVAMLHLVNNMTI
PVSIWGSKSVIMWSGVQDAMVQWWYGHNAVGFFLTAGFLGMMYYFVPKQAERPVFSYKLS
IIHFWALIFLYIWAGPHHLHYTALPDWASTLGMVFSIVLWMPSWGGMINGLMTLSGAWDK
LRTDPVIRMMVISIGFYGMSTFEGPMMSIRAVNSLSHYTDWTIGHVHSGALGWNGMITFG
ALYFLVPVLWKRERLYSLSLVSWHFWLATIGIILYAASMWVTGIMEGLMWREVDANGFLV
NSFADTVAAKFPMYVVRALGGVMFLAGALIMCYNLWMTVRRAPAKEASLTVAVPAE