Protein Info for PGA1_c30090 in Phaeobacter inhibens DSM 17395

Annotation: cytochrome c oxidase subunit 3

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 289 transmembrane" amino acids 32 to 54 (23 residues), see Phobius details TIGR00782: cytochrome c oxidase, cbb3-type, subunit III" amino acids 8 to 289 (282 residues), 412.5 bits, see alignment E=4.5e-128 PF14715: FixP_N" amino acids 13 to 57 (45 residues), 87.5 bits, see alignment 5.6e-29 PF13442: Cytochrome_CBB3" amino acids 110 to 194 (85 residues), 46.7 bits, see alignment E=5.1e-16 amino acids 207 to 282 (76 residues), 44.1 bits, see alignment E=3.2e-15 PF00034: Cytochrom_C" amino acids 111 to 198 (88 residues), 45.1 bits, see alignment E=3.2e-15 amino acids 207 to 285 (79 residues), 43.3 bits, see alignment E=1.2e-14

Best Hits

Swiss-Prot: 65% identical to CCOP_RHOS4: Cbb3-type cytochrome c oxidase subunit CcoP (ccoP) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

KEGG orthology group: K00406, cb-type cytochrome c oxidase subunit III [EC: 1.9.3.1] (inferred from 76% identity to sit:TM1040_2542)

MetaCyc: 54% identical to cytochrome cbb3 oxidase subunit III (Rhodobacter capsulatus)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase subunit CcoP (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E4E9 at UniProt or InterPro

Protein Sequence (289 amino acids)

>PGA1_c30090 cytochrome c oxidase subunit 3 (Phaeobacter inhibens DSM 17395)
MSKKVKKFEDDPNTTGHSWDGIEEFDNPMPRWWLWTFYATIIWAIGYTVAYPAWPGIQSA
TAGVLGWNSRALVAEEIAAVNEANAPINSRLEEIELASITTDPELNGYAVSAGSAVFKTW
CAQCHGAGAAGAKGYPNLLDDDWLWGGSMEDIHATIAHGIRNEESDDARYSEMPAFGRDE
LLEKEEIDQVVNYVMSLSGEPQDADKVAPGAAIFADNCASCHMEDGTGDRSQGAPNLADA
IWLYGGDHATLTETVYNSRYGVMPNWNARLTEAQIRAVTAYVHQLGGGE