Protein Info for PGA1_c30050 in Phaeobacter inhibens DSM 17395

Annotation: heavy metal translocating ATPase CcoI

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 726 transmembrane" amino acids 115 to 136 (22 residues), see Phobius details amino acids 147 to 167 (21 residues), see Phobius details amino acids 179 to 200 (22 residues), see Phobius details amino acids 207 to 225 (19 residues), see Phobius details amino acids 362 to 382 (21 residues), see Phobius details amino acids 388 to 416 (29 residues), see Phobius details amino acids 687 to 711 (25 residues), see Phobius details PF00403: HMA" amino acids 36 to 93 (58 residues), 37.7 bits, see alignment 3.3e-13 TIGR01511: copper-translocating P-type ATPase" amino acids 162 to 726 (565 residues), 491 bits, see alignment E=1.1e-150 TIGR01525: heavy metal translocating P-type ATPase" amino acids 181 to 725 (545 residues), 493.6 bits, see alignment E=1.8e-151 TIGR01512: cadmium-translocating P-type ATPase" amino acids 207 to 725 (519 residues), 325.3 bits, see alignment E=1.3e-100 TIGR01494: HAD ATPase, P-type, family IC" amino acids 216 to 466 (251 residues), 109 bits, see alignment E=4.2e-35 amino acids 549 to 707 (159 residues), 107.9 bits, see alignment E=9e-35 PF00122: E1-E2_ATPase" amino acids 245 to 423 (179 residues), 144.9 bits, see alignment E=3.1e-46 PF00702: Hydrolase" amino acids 439 to 637 (199 residues), 97.1 bits, see alignment E=2.7e-31

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 77% identity to sit:TM1040_2538)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F2N8 at UniProt or InterPro

Protein Sequence (726 amino acids)

>PGA1_c30050 heavy metal translocating ATPase CcoI (Phaeobacter inhibens DSM 17395)
MSTAVRPQLAACPGCVAAPNGTIEQAPTEARLALSLPSIHCQACISTVERGLNAVPGVRS
ARVNLTLKRALIEADPEVRALDLVPVLERLGFEAHELNLAALSATQTDQAGRDLLMRLAV
AFFASMNVMLLSISVWSGASDATRDMFHWISAAITFPAILFAGQPFFRNAWQALRVGRLN
MDVPIVLAIVLALLTSLWETSLSGEHAYFDAALTLTFFLLAGRYLDHRTRAVARSAAEEL
AALEVPRALRLDSAGQPVEVAVADLVIDDHILVRPGGRMPVDGVVLEGQSELDRSLLTGE
TLPVFAEAGSLISAGEVNLTGPLVVGATAVGTQSSLHQLADLVAIAESGRSRYTSLADRA
AKLYAPGVHILSALAFLGWYLFTFDLRVALNIAAAVLIITCPCALGLAVPAVTTAASGRL
FKKGMLIKHSTALERLAEVDTVVFDKTGTLTNGTPQCDDFALLSPQDQQLAYALARGSDH
PLSAAICRAAEQAGVRPAVVTGLQEVPGFGTEASYHDRRVRLGRAAWVGAEPGAKTATYL
DNGAGRAQALTFSDILRPGAAEAVEALQKANKNVWLISGDTEGAVRDLAERLKIQHWIAS
ALPQDKSGCVAELSEQGQRVLMVGDGLNDTAALAAAHVSISPASALDAARVASDIVLLGQ
DLAPIAEACVVAQKATYRIRENFRIATLYNVIAVPLAVAGLATPLVAALAMSTSSITVSL
NALRLR