Protein Info for PGA1_c29630 in Phaeobacter inhibens DSM 17395

Annotation: creatinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01321: Creatinase_N
  • amino acids 28 to 157 (130 residues), 45.4 bits, E=1.2e-15
• PF00557: Peptidase_M24
  • amino acids 166 to 382 (217 residues), 105.3 bits, E=3.9e-34

Best Hits

Swiss-Prot: 58% identical to CREA_FLASU: Creatinase from Flavobacterium sp. (strain U-188)

KEGG orthology group: K08688, creatinase [EC: 3.5.3.3] (inferred from 87% identity to sit:TM1040_2491)

Predicted SEED Role

"Creatinase (EC 3.5.3.3)" (EC 3.5.3.3)

MetaCyc Pathways

• creatinine degradation I (2/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.3

Sequence Analysis Tools

See I7E4A6 at UniProt or InterPro

Protein Sequence (402 amino acids)

>PGA1_c29630 creatinase (Phaeobacter inhibens DSM 17395)
MTSRPEMYRFHNGEKAPLQFAVSEYEARIAGLRKIMAETGVTAAVFTSMHNISYYSGFTY
CAFGRPYGMVVTASEAVTISAGIDAGQPWRRSFCDNITYTDWQRDNFWRAIKSVSGDGAV
VGYESDHLTLLQKAKLEHFLTPSQLVDLYEPTMRQRMGKSAAELDMIRAGAAVADVGGFA
IRDAVKEGAREIDVAMAGRDAMELEIAKRFPDAEYRDSWVWFQSGINTDGAHNPVTARTL
QRGDILSLNTFPMISGYYTALERTMFVKEVDAESLRIWEANVAAHELGISLLKPGASCAE
ITHQINAFFEEQDLLQYRTFGYGHSFGVLSHYYGREAGLELREDIDTVLEPGMVISMEPM
LTIADGQPGAGGYREHDILIIHEDDNENITKYPYGPEFNVVG