Protein Info for PGA1_c29390 in Phaeobacter inhibens DSM 17395

Annotation: penicillin-binding protein, 1A family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 758 transmembrane" amino acids 84 to 100 (17 residues), see Phobius details amino acids 106 to 126 (21 residues), see Phobius details PF00912: Transgly" amino acids 162 to 347 (186 residues), 180.3 bits, see alignment E=2.5e-57 TIGR02074: penicillin-binding protein, 1A family" amino acids 164 to 708 (545 residues), 519.5 bits, see alignment E=5.7e-160 PF00905: Transpeptidase" amino acids 434 to 672 (239 residues), 108 bits, see alignment E=5.5e-35

Best Hits

KEGG orthology group: None (inferred from 76% identity to sit:TM1040_2628)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F2I7 at UniProt or InterPro

Protein Sequence (758 amino acids)

>PGA1_c29390 penicillin-binding protein, 1A family (Phaeobacter inhibens DSM 17395)
MAQGTRRRPLVADKRYATAGRGTQGKASARKAKPRPKSAPKARKSGWFTLFSGGGKTGGK
AGSTRGGSGGGGRGPRKPRKPKTLLGRLLALILAPFRWAFRLAWGFTWRIGMISTALVAL
AVGYHYMKLPEVAELLDGRARGSVTLTDRNGEVFAWRGDQFGGVVTSETVSPYLKNAIVA
TEDKRFYRHFGVSPRGVASAVRINLREGRGPLSGHGGSTITQQTAKLLCLGVVFDPTEWE
SERAYERDCRQGSLWRKAKEAIFAMAMEAKYTKDEILSIYMNRAYLGGGAYGAEAAAQRY
FGKSANQVDASEAAMLAGLLTAPSTLAPTNNLQRSQDRAATVLRLMQEQGYLTTSEMRSA
QNSPAVLSEAAAARAGGYFADWVMDTIPDFFGSETTEDVVIRTTIDQRLQRAAEDALNHV
FDTKVREGSKAQAAIVVMSADGAVRAMVGGRKSRVSGVFNRATQAKRQTGSAFKPFVYAT
ALELGYSPLDRVLDAQYCLDVPGSGQWCPKNYTRKFYGEVTLARALRDSLNVPAVKVSEA
VGRDLVRRVAGDFGLDSELAAGPALALGASESTLLEMTGAYAGILNGGSSVTPYGVTELT
LIGDNTPMMGASGGLGERVIQTKAARELIWMMEQVVSQGSGRRAQIPGWQAAGKTGTTQA
ARDAWFVGFTADYVAGVWMGYDDNTPLSGVTGGGLPADIWREVMVRVHDGLPPKPLPMIA
PKPIAPPPQPQPQRRQRPNVGQELGRAVDGLLRDIFGN