Protein Info for PGA1_c29350 in Phaeobacter inhibens DSM 17395

Annotation: alkaline protease secretion ATP-binding protein AprD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 576 transmembrane" amino acids 22 to 45 (24 residues), see Phobius details amino acids 58 to 78 (21 residues), see Phobius details amino acids 131 to 154 (24 residues), see Phobius details amino acids 160 to 180 (21 residues), see Phobius details amino acids 250 to 267 (18 residues), see Phobius details amino acids 273 to 295 (23 residues), see Phobius details TIGR01842: type I secretion system ATPase" amino acids 21 to 559 (539 residues), 669 bits, see alignment E=2.5e-205 PF00664: ABC_membrane" amino acids 27 to 283 (257 residues), 45.1 bits, see alignment E=1.1e-15 PF00005: ABC_tran" amino acids 350 to 498 (149 residues), 113.1 bits, see alignment E=1.6e-36

Best Hits

Swiss-Prot: 43% identical to APRD_PSEAE: Alkaline protease secretion ATP-binding protein AprD (aprD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K06148, ATP-binding cassette, subfamily C, bacterial (inferred from 75% identity to sil:SPO3728)

Predicted SEED Role

"Type I secretion system ATPase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DU32 at UniProt or InterPro

Protein Sequence (576 amino acids)

>PGA1_c29350 alkaline protease secretion ATP-binding protein AprD (Phaeobacter inhibens DSM 17395)
MMKTSHKSGLEELRAHRRRSRGLYWSVGIFSFFVNMLMLTGPLYMMQVYDRVLGSRSVAT
LIALSLLVVFLYGTMGVLDYARGRILARVGARFQAGLDQRVFDAMIRRSAVAQDPVAQTG
LSDLESVQRLIASPVLGAAFDLPWTPIFLFGIALFHPWLGMLALGGGAVLIAIAVLNQFL
SRRPQMQAGMSGHRANLMSEEIRTEAEMIQSMGMRRAAFQRWKAGRDAALVDSVTASDVG
GGFTTLTKTLRLFLQSAMLGLGAYLVLQNEVTAGAMIAGSILMGRALAPIELALGQWAMV
QRALKGWRNLAELLDKVPEEAERTELPKPTANLEVQALAVVPPGDNRPQLRNVSFRVQPG
QAIGVIGPSGSGKSTLARALTGAWRPAAGTVRLDGASLDQYAPEVLGQNIGYLPQRVQLF
EGTIAQNIARLSPNPDSEKVVAAAKKAAAHDMIVHLPDGYDTHITAGGGRLSGGQMQRVA
LARALYDDPVIVILDEPNSNLDNDGSVALNRAIKQLKADGHSVLIMAHRPAAIQECDLLL
VIDQGVQTAFGPKDKVLREMVSNHQSIQQAAPGGVR