Protein Info for HP15_2772 in Marinobacter adhaerens HP15

Annotation: N-isopropylammelide isopropylaminohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 414 PF07969: Amidohydro_3" amino acids 42 to 400 (359 residues), 159.7 bits, see alignment E=1.9e-50 PF01979: Amidohydro_1" amino acids 49 to 397 (349 residues), 50 bits, see alignment E=2.7e-17

Best Hits

Swiss-Prot: 58% identical to CODA_ECOLI: Cytosine deaminase (codA) from Escherichia coli (strain K12)

KEGG orthology group: K01485, cytosine deaminase [EC: 3.5.4.1] (inferred from 64% identity to pfs:PFLU2109)

MetaCyc: 60% identical to cytosine deaminase monomer (Klebsiella pneumoniae)
Cytosine deaminase. [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]

Predicted SEED Role

"Cytosine deaminase (EC 3.5.4.1)" (EC 3.5.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PLE5 at UniProt or InterPro

Protein Sequence (414 amino acids)

>HP15_2772 N-isopropylammelide isopropylaminohydrolase (Marinobacter adhaerens HP15)
MNAIANARLQGRDGLFRLEISNGRFSGITAQAENTTANEGELDAGGNLVTAPFVEPHIHL
DAAMTAGEPRWNKSGTLFEGIECWSERKKTLSHDDVISRASQTLKLFAAHGIQYVRTHVD
VTDPNLTALKAMLEVREQTASFVDLQIVAFPQEGIWSFKNGRELMEEAVRLGADVVGGIP
HFEFTRDYGAESVRWLMELAHKNDRLVDVHCDEIDDPESRFLEVLAAEALRLDYGSRVSA
SHTCAMGSYNDAYCSRLFRLLKKSGLRFLSMPTESLHLQGRFDSYPKRRGITRVPELLDA
GLKVAFGQDSIRDPWYPMGNGNMLRTLDVGLHACHMLGMSWIDRSLELITENGAAALDLD
EYGLDEGMPARCVVLQGATPYEVLLGQRPVLASVRDGQVLVRREACHPGTGLML