Protein Info for Psest_2827 in Pseudomonas stutzeri RCH2

Annotation: DNA-directed DNA polymerase III (polc)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1173 TIGR00594: DNA polymerase III, alpha subunit" amino acids 5 to 1045 (1041 residues), 1294.6 bits, see alignment E=0 PF02811: PHP" amino acids 7 to 171 (165 residues), 153.4 bits, see alignment E=2.2e-48 PF07733: DNA_pol3_alpha" amino acids 291 to 559 (269 residues), 341.3 bits, see alignment E=1.3e-105 PF17657: DNA_pol3_finger" amino acids 562 to 736 (175 residues), 227.6 bits, see alignment E=1.7e-71 PF14579: HHH_6" amino acids 810 to 893 (84 residues), 95.7 bits, see alignment 4.7e-31 PF01336: tRNA_anti-codon" amino acids 1009 to 1085 (77 residues), 45.6 bits, see alignment 1.6e-15 PF20914: DNA_pol_IIIA_C" amino acids 1122 to 1164 (43 residues), 46.2 bits, see alignment (E = 9.8e-16)

Best Hits

Swiss-Prot: 88% identical to DPO3A_PSEAE: DNA polymerase III subunit alpha (dnaE) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GNF0 at UniProt or InterPro

Protein Sequence (1173 amino acids)

>Psest_2827 DNA-directed DNA polymerase III (polc) (Pseudomonas stutzeri RCH2)
MPVSFVHLRLHTEYSLVDGLVRVKPLIKAVAAGGMPAVAVTDMSNMCSLVKFYKTAQGSG
IKPICGADIWMAGCDEDGPLSRLTLLAMNPKGYRNLTELISRGWTEGQRNDLVIIERDWV
KLAAEGLIALSGAKEGEVGQALLNGDEALAEARLAEWRDVFADRFYLEIQRTSRVNDEEH
LHAAAALADRTGTPLVATNDVRFLKQEDFEAHETRVCIGEGRTLDDPRRPRTYSDQQYLK
TPAEMAELFSDLPEALENTVEIAKRCNIEVQLGTYFLPNFPVPEGMTIDDYLRQVSFEGL
EERLEVLLPKDTPDYEAKKQVYIDRLEFELGTIIQMGFPGYFLIVMDFIKWAKNNGVPVG
PGRGSGAGSLVAYVLKITDLDPLAYDLLFERFLNPERVSMPDFDVDFCMDGRDRVIDYVA
EAYGRNAVSQIITFGTMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYEMEE
PLRDFLAVDEDAREIWEMALKLEGITRGTGKHAGGVVIAPTKLTDFAPIACDEEGGGLVT
QFDKDDVESAGLVKFDFLGLRTLTIIKWALETINREQAKKGLEPINIDFIPLDDKPTYQL
LQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALFRPGPLQSGMVDDFINRKHGRA
EVSYPHPDYQYAGLEPVLKPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKPEE
MAKQRGGFIEGCSNNGIDKELSGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYP
SPFMAAVLSADMHNTDKVVILIEECRSMKLRIDPPDVNVSEFKFTVNDDGRIVYGLGAVK
GVGEGPVEAIAECRAEGGPFKDLFDFCARIDLKRINKRTLEALIRSGALDRLGPYFFEEA
KAYQANIDRNRAVLLAAMEEAVQAAEQTARSAESGHMDLFGGLFAEPEADVYANHRNARE
LSLKERLKGEKDTLGLYLTGHPIDEYEGEVRRFARQRIIDLRPARGEQTIAGLIVNLRVM
KNKKGDKMGFITLDDRSGRIEASLFAEAFNSAQALLQTDALVVVEGEVSNDDFSGGLRLR
AKRVMSLEEARTGLAESLRVKVAGEALRGERMRWLAEVCGRHRGACPITLEYTGRDARAL
LQFGEEWRIDPADNLIQALRDQFGRDNVFLQYR