Protein Info for PGA1_c28110 in Phaeobacter inhibens DSM 17395

Annotation: xanthine dehydrogenase XdhB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02965: xanthine dehydrogenase, molybdopterin binding subunit
  • amino acids 3 to 797 (795 residues), 1201.9 bits, E=0
• PF01315: Ald_Xan_dh_C
  • amino acids 17 to 124 (108 residues), 98.7 bits, E=3.7e-32
• PF02738: MoCoBD_1
  • amino acids 145 to 377 (233 residues), 295.5 bits, E=3.5e-92
• PF20256: MoCoBD_2
  • amino acids 445 to 729 (285 residues), 328.4 bits, E=6.9e-102

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• purine nucleotides degradation II (aerobic) (10/11 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• guanosine nucleotides degradation III (4/4 steps found)
• inosine 5'-phosphate degradation (4/4 steps found)
• ureide biosynthesis (6/7 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Sequence Analysis Tools

See I7EZV6 at UniProt or InterPro

Protein Sequence (801 amino acids)

>PGA1_c28110 xanthine dehydrogenase XdhB (Phaeobacter inhibens DSM 17395)
MAVAKPLHHDAARLHVTGQARYVDDIPTPRDTLHLAFGLSTVAHGDITAMNLDAVRQSDG
VVAVLTAEDLPFDNDVSPSAHDEPLLAKGSVHYIGQPVFLVVATSHRAARVAARKGQISY
AERPALLTLGDALAANSRFEDGPRIYSKGDADSAIQTAAHVVEDTFDLGGQEHFYLEGQA
ALAQPQEDGGMLVNSSTQHPTEIQHKVAEAIGLPMHAVRVETRRMGGGFGGKESQGNALA
VACAIAARATGRTCKMRYDRDDDMTITGKRHAFHISYRAGFDAEGRIQGVKFTHLVDCGW
AQDLSLPVADRAMLHSDNAYLIPAIRIESHRLKTNRQSATAYRGFGGPQGMVGIERLMDH
AAHALGLDPVALRQRNYYAPMQSPTAPSGDPHDSSAPAPGATGDLASRGAPAEPADVTTP
AKDVQTTPYHMPVEDFVLHELTAELLNTSDYAARRAEIAKWNAGNDRLKRGIGFSPVKFG
ISFTLTHLNQAGALVHVYQDGSVHLNHGGTEMGQGLFQKVAQVAASRFGISLEKVKITAT
DTAKVPNTSATAASSGTDLNGMAVKAACDTIRDRMAAYLAERYQQPVAAVRFEGDRVIIG
SEELSFEAAAMECYTGRISLSATGFYKTPKLEWDRIQGKGRPFFYFAYGAAITEVVVDRL
TGENRILRADVLHDAGASLNPALDIGQVEGAYVQGAGWLTTEELVWDQTGNLRTHAPSTY
KIPACSDRPDLFNVALWNGENREDSIYRSKAVGEPPFMLGISAWLALSDAVGAYGGDYPA
LNAPATAEELWRAVRRIAPGA