Protein Info for HP15_2659 in Marinobacter adhaerens HP15

Updated annotation (from data): Citrate uptake transporter, large transmembrane component TctA
Rationale: Specifically important for citrate utilization.
Original annotation: tricarboxylic transport TctA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 508 transmembrane" amino acids 16 to 40 (25 residues), see Phobius details amino acids 45 to 73 (29 residues), see Phobius details amino acids 111 to 134 (24 residues), see Phobius details amino acids 141 to 163 (23 residues), see Phobius details amino acids 172 to 189 (18 residues), see Phobius details amino acids 206 to 225 (20 residues), see Phobius details amino acids 259 to 281 (23 residues), see Phobius details amino acids 321 to 344 (24 residues), see Phobius details amino acids 356 to 380 (25 residues), see Phobius details amino acids 390 to 408 (19 residues), see Phobius details amino acids 415 to 444 (30 residues), see Phobius details amino acids 465 to 489 (25 residues), see Phobius details PF01970: TctA" amino acids 20 to 440 (421 residues), 505.2 bits, see alignment E=6.2e-156

Best Hits

KEGG orthology group: K07793, putative tricarboxylic transport membrane protein (inferred from 95% identity to maq:Maqu_2895)

Predicted SEED Role

"Tricarboxylate transport membrane protein TctA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJQ9 at UniProt or InterPro

Protein Sequence (508 amino acids)

>HP15_2659 Citrate uptake transporter, large transmembrane component TctA (Marinobacter adhaerens HP15)
METLGFLMDGFAVALTPYNLMFALFGAFVGTLIGCLPGLGPANGVAILIPLAFTLGLPPE
TAMILLTAVYAGAMYGGRISSILLNIPGDEPAMMTCLDGYPMAQKGRAADALAVSAIASF
AGGLIGTIGLIMLAPVLAKFALTFGPAEYFALFLLAFATLGGITGKNPVKTVVAATLGIM
ISTVGIDISTGTQRYTFGVLELYEGIDFILAIVGLFAISELLFFVESRMGRGRDKMNVGK
LTLTMKELVMTIPTQLRGGVLGFISGVLPGAGASLGSFISYTLEKQVVGKKGKFGEGDIR
GVVAPEAGNNGASSGALVPMLTLGVPGSGTTAVLLAMLISLNITPGPLMFTQNADIVWGV
IAALLIGNVLLLVLNIPLVGFFVKLLSVPPMYLLPIVTMVAFVGIYSISHSTFDLYFMVA
FGVAGYFLRKLEIPLVPIILGLLLGPEMEKNLGHALVLSDGEWSVLWASPLAMGLWIVAG
LGLILPYLVGPLLRRRMNAAMKESPVSD