Protein Info for PGA1_c27280 in Phaeobacter inhibens DSM 17395

Annotation: signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 626 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 316 to 334 (19 residues), see Phobius details PF00672: HAMP" amino acids 337 to 377 (41 residues), 34.2 bits, see alignment 3.9e-12 PF00512: HisKA" amino acids 393 to 458 (66 residues), 33.2 bits, see alignment E=6.5e-12 PF02518: HATPase_c" amino acids 503 to 611 (109 residues), 85.8 bits, see alignment E=4.2e-28

Best Hits

Predicted SEED Role

"sensory box histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F234 at UniProt or InterPro

Protein Sequence (626 amino acids)

>PGA1_c27280 signal transduction histidine kinase (Phaeobacter inhibens DSM 17395)
MSLTARLRSCVVICLASICVAMYAEWNDLSRIERKTENLSDRTIPLLDRIADLGDLQHGL
EVTLARVRLIDDLDGLAGMGRRVDNLSQLFRENFSDREDTIAEELSSADADVFQNVVKGR
QDIVAQNIRINALVSQAVDKILALEKSIVVAQIEFGNQQRDAQSRQEGSLSVTWAIDTAK
TLGEISGSVASLAILTKDFSLETGTGNTGARQSLVAEINILASRLARLKNLEARHDIAGV
LVDYRNTMLGPDGVVEALSALQTRQAGQEQLYGEAEAVLNNIGAWTRSSTQRAAMEFRQS
AAETSRIVERIRFVDVAFNMCMLLISLALLWFMIEVRMISRIHRLTRHIQRMSRGHLEDP
IDTAGSDEIAEIAKAVEKSRLTAAALQRSNEELERFAYVAAHDLRAPLRAISNLIEWTEE
DFADEMPADAQKNIGLIRNRTDRLSGHLSALLDYARAGQIDGEHGAFSLTKFAEELRLYF
NSNSAFEIRVEQDCGPFGAYLTPLKTILINLVSNASKHHDRSSGTIRMSSELYPNYVEIT
VADDGPGIPKQYQDQIFVLFQTLKSRDEVEGSGLGLALVQKLARSLGGSVSVVSNPDVAR
GTVFTVRVPLNTPSAKTPNDIQGLAA