Protein Info for HP15_2623 in Marinobacter adhaerens HP15

Annotation: leucine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 371 PF02812: ELFV_dehydrog_N" amino acids 28 to 136 (109 residues), 92.9 bits, see alignment E=2e-30 PF00208: ELFV_dehydrog" amino acids 159 to 208 (50 residues), 25.7 bits, see alignment 1.3e-09 amino acids 227 to 303 (77 residues), 45.7 bits, see alignment E=1.1e-15

Best Hits

Swiss-Prot: 48% identical to DHLE_GEOSE: Leucine dehydrogenase (ldh) from Geobacillus stearothermophilus

KEGG orthology group: K00263, leucine dehydrogenase [EC: 1.4.1.9] (inferred from 86% identity to maq:Maqu_2878)

Predicted SEED Role

"Leucine dehydrogenase (EC 1.4.1.9)" in subsystem Branched-Chain Amino Acid Biosynthesis or Leucine Degradation and HMG-CoA Metabolism (EC 1.4.1.9)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJM3 at UniProt or InterPro

Protein Sequence (371 amino acids)

>HP15_2623 leucine dehydrogenase (Marinobacter adhaerens HP15)
MGEDFTMLFSHPEFDNHEHLSFFCDPETGLKAIVAIHNTSRGPALGGCRMFPYASDEEAV
RDVLRLSRGMTYKSALANLDLGGGKSVIIGDPRKQKTEALMEAMGRHLESLGGQYIAAED
SGTSVPDLKVMGRHTSHVAGIASRTGFDGNPSNGDPSPATAYGTFIGLKAAVKHKLGRDD
LNGLKVAIQGIGNVGFRLARHLKDAGADLWVYDIHDDNMRRAVDQLGAKPAAAEDILSLP
VDVVAPCAMGAVLNDDSIPQLKARIVAGAANNLLEHPEHDAMLQDRGVLYAPDFAINAGG
IIDVFYERAGATPETVRAHVDTIGDTLTEIFNRSDRSGRPTGEIANELAEERFKKHTAGA
GQASERLARTG