Protein Info for HP15_2615 in Marinobacter adhaerens HP15

Annotation: two component transcriptional regulator, winged helix family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 228 PF00072: Response_reg" amino acids 5 to 113 (109 residues), 104.6 bits, see alignment E=3.5e-34 PF00486: Trans_reg_C" amino acids 153 to 223 (71 residues), 73.1 bits, see alignment E=1.6e-24

Best Hits

Swiss-Prot: 38% identical to MPRA_MYCSJ: Response regulator MprA (mprA) from Mycobacterium sp. (strain JLS)

KEGG orthology group: None (inferred from 91% identity to maq:Maqu_2869)

Predicted SEED Role

"Copper-sensing two-component system response regulator CpxR" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJL5 at UniProt or InterPro

Protein Sequence (228 amino acids)

>HP15_2615 two component transcriptional regulator, winged helix family (Marinobacter adhaerens HP15)
MQNRVLLVEDDDELRELLARYLTNQGFTIREAANGRDGLALALGQDCDIVVLDIMLPDIS
GLEVLRELRAETHLPVVLLTARGDETDRIVGFEVGADDYIPKPCNPRELVARLQALLRRI
AWDQKTEVNAARTYGDLRVEPGHRRIYQNDVAMELTATEYEVLQVLLAHAGSVVRKTDLM
QWALGRRLEAYDRTLDMHISNLRKKLGNDDPPRIETVRGLGYSYRVPE