Protein Info for Psest_2721 in Pseudomonas stutzeri RCH2

Annotation: HD-GYP domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 transmembrane" amino acids 167 to 185 (19 residues), see Phobius details PF11871: DUF3391" amino acids 21 to 138 (118 residues), 84.5 bits, see alignment E=1.6e-27 PF01966: HD" amino acids 172 to 291 (120 residues), 57.4 bits, see alignment E=2.7e-19 PF13487: HD_5" amino acids 176 to 323 (148 residues), 91 bits, see alignment E=1.1e-29

Best Hits

KEGG orthology group: None (inferred from 85% identity to psa:PST_1647)

Predicted SEED Role

"metal dependent phosphohydrolase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GPI3 at UniProt or InterPro

Protein Sequence (429 amino acids)

>Psest_2721 HD-GYP domain (Pseudomonas stutzeri RCH2)
MRRTSQSDNHTDTLLVPTRRRVAVASLELGMYVCELDRPWSETNFAFQGFPLLTPGEIRK
VRSCCDYVYVDDTRRVRLQHGVPVATATPRARKPQERTYHALSTEVEEARSAYQDGSQLI
EQVLADVQHGRVIDTRACHGAVKRNLESMLRNESAMLWLIRLKNKDLYTSLHCLSVSIMA
MGFGNHLGLQDDKLQLLGMAGLLHDVGKMRIDPQILNKPGKLTSQEFEVIKRHPVFGLEA
LRAQPGVPEAALHAAYGHHERLDGTGYPLGSGPAQISYMTRIITIVDAFDAITSHRAYDC
ARPVQAAFEILRSGSGRQFDEDLVLEFIRWLGAFPVGTLVELHTGEVAVVVEKHKQFQLR
PRVVVLRDAAKQRCAARYLDLAQVTVDAEGTPYRISIGLPDGSFGLHIADPELQSILHPQ
TLASFEQDA