Protein Info for PGA1_c27060 in Phaeobacter inhibens DSM 17395

Annotation: putative signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 592 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 277 to 301 (25 residues), see Phobius details PF07536: HWE_HK" amino acids 371 to 436 (66 residues), 30.7 bits, see alignment E=4.3e-11 PF07568: HisKA_2" amino acids 371 to 443 (73 residues), 78.1 bits, see alignment E=4.4e-26

Best Hits

Predicted SEED Role

"FIG00989364: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E3P5 at UniProt or InterPro

Protein Sequence (592 amino acids)

>PGA1_c27060 putative signal transduction histidine kinase (Phaeobacter inhibens DSM 17395)
MRLGRALAGGLFFRLAALMTLALLPLGMIAIYQTYSVIDEAARLSRVAILARAENAALAE
RELLQRTNGAAEALSAIALPLSDQPGACNAMMTSFVAEQAAYSFAGLYRPDGQRVCSSGG
GQASIANTPIFQRALSRDTPSYGVGRNLDGSDGFELSLTRPIEEAGRAVAYLVLAIPNRL
TSSFFTDDWKLEGIRFATINEEGDVLSASEPRSEAGLILPQASLREDLMARSGETFFAVS
NAGEERFFAVSDIIPGQIAVVGSWPAAQAKMATGAGGWVFTLAFPVLMWLAGMVVGVFGL
HRLVIRHLSDLRAAMRRYALGEREQAQLELINPPREFAEAQQSFNRMVLILSKAEERREI
DLREKTILLREIHHRVKNNLQLIASIMNMQARSARSDEARTVLAQLQRRVRGLAAIHRSL
NTNPDVTTVDAAELITALAKEVAAMSLGSDAVVSIETKLETVPLNQDDAVNLSMLVAEAL
TNAVRYAGATEDGRRVVQVFFGEEKASMCRLAIHNALDPQSGLAHEDRHFTSGLGARLIK
AFVAQLNGDAKVTETETEFTYEVVFPRSDDTAAAALAEQKGANDNADLRHTG