Protein Info for HP15_2594 in Marinobacter adhaerens HP15

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF06865: Ppnp
  • amino acids 3 to 92 (90 residues), 112.9 bits, E=3.8e-37

Best Hits

Swiss-Prot: 79% identical to PPNP_MARHV: Pyrimidine/purine nucleoside phosphorylase (ppnP) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K09913, hypothetical protein (inferred from 79% identity to maq:Maqu_2862)

MetaCyc: 53% identical to nucleoside phosphorylase PpnP (Escherichia coli K-12 substr. MG1655)
Pyrimidine-nucleoside phosphorylase. [EC: 2.4.2.2, 2.4.2.4]; Uridine phosphorylase. [EC: 2.4.2.2, 2.4.2.4, 2.4.2.3]; Purine-nucleoside phosphorylase. [EC: 2.4.2.2, 2.4.2.4, 2.4.2.3, 2.4.2.1, 2.4.2.15]; 2.4.2.1 [EC: 2.4.2.2, 2.4.2.4, 2.4.2.3, 2.4.2.1, 2.4.2.15]; 2.4.2.1 [EC: 2.4.2.2, 2.4.2.4, 2.4.2.3, 2.4.2.1, 2.4.2.15]; 2.4.2.1 [EC: 2.4.2.2, 2.4.2.4, 2.4.2.3, 2.4.2.1, 2.4.2.15]

Predicted SEED Role

"FIG074102: hypothetical protein"

MetaCyc Pathways

• superpathway of purine nucleotide salvage (13/14 steps found)
• adenine and adenosine salvage III (4/4 steps found)
• purine ribonucleosides degradation (5/6 steps found)
• adenine and adenosine salvage I (2/2 steps found)
• guanine and guanosine salvage I (2/2 steps found)
• xanthine and xanthosine salvage (2/2 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• adenine and adenosine salvage V (2/3 steps found)
• superpathway of guanine and guanosine salvage (2/3 steps found)
• pyrimidine ribonucleosides degradation (1/2 steps found)
• adenosine nucleotides degradation II (3/5 steps found)
• guanosine nucleotides degradation III (2/4 steps found)
• pyrimidine deoxyribonucleosides degradation (1/3 steps found)
• ureide biosynthesis (3/7 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (2/6 steps found)
• superpathway of pyrimidine ribonucleosides degradation (1/5 steps found)
• nucleoside and nucleotide degradation (halobacteria) (1/6 steps found)
• superpathway of purine deoxyribonucleosides degradation (1/7 steps found)
• nucleoside and nucleotide degradation (archaea) (3/10 steps found)
• salinosporamide A biosynthesis (2/15 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Nicotinate and nicotinamide metabolism
• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.4

Use Curated BLAST to search for 2.4.2.1 or 2.4.2.15 or 2.4.2.2 or 2.4.2.3 or 2.4.2.4

Sequence Analysis Tools

See E4PIV7 at UniProt or InterPro

Protein Sequence (93 amino acids)

>HP15_2594 hypothetical protein (Marinobacter adhaerens HP15)
MLQVNEYFEGQAKSISFQTSTLPATVGVISPGEYEFGTSKKETMTVISGALTVLLPGMEE
WMTYGAGESFDVAGQASFKAKTDIDTAYLCTYE