Protein Info for PGA1_c26670 in Phaeobacter inhibens DSM 17395

Annotation: bifunctional adenosylcobalamin biosynthesis protein CobP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02283: CobU
  • amino acids 6 to 167 (162 residues), 189.9 bits, E=1.3e-60

Best Hits

Swiss-Prot: 46% identical to COBP_SINSX: Bifunctional adenosylcobalamin biosynthesis protein CobP (cobP) from Sinorhizobium sp.

KEGG orthology group: K02231, adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC: 2.7.1.156 2.7.7.62] (inferred from 68% identity to sil:SPO0405)

MetaCyc: 46% identical to CobP (Pseudomonas denitrificans (nom. rej.))
Adenosylcobinamide-phosphate guanylyltransferase. [EC: 2.7.7.62]; Adenosylcobinamide kinase. [EC: 2.7.7.62, 2.7.1.156]; 2.7.1.156 [EC: 2.7.7.62, 2.7.1.156]; 2.7.1.156 [EC: 2.7.7.62, 2.7.1.156]

Predicted SEED Role

"Adenosylcobinamide kinase (EC 2.7.1.156) / Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 2.7.1.156, EC 2.7.7.62)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (28/33 steps found)
• adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide (6/6 steps found)
• adenosylcobinamide-GDP salvage from cobinamide I (5/5 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide I (7/8 steps found)
• adenosylcobinamide-GDP salvage from cobinamide II (5/6 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide II (7/9 steps found)
• adenosylcobinamide-GDP salvage from assorted adenosylcobamides (1/2 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (24/36 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.156 or 2.7.7.62

Sequence Analysis Tools

See I7F1Z2 at UniProt or InterPro

Protein Sequence (172 amino acids)

>PGA1_c26670 bifunctional adenosylcobalamin biosynthesis protein CobP (Phaeobacter inhibens DSM 17395)
MPSKVTFILGGAASGKSAFAESLCLSSGKDRVYLATSQVFDDEMRAKIDRHLHQRGTGWT
TNEAPMDLAPVLDSLAADQICLVDCATMWLSNQMLAEADLQAAQHHLLDALQRCAAEVVV
VSNEVGHGIVPDNALARQFREAQGRLNIALAGMADRAVLVTAGLPQVLKGTL