Protein Info for HP15_2539 in Marinobacter adhaerens HP15

Annotation: acyl-CoA dehydrogenase domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 386 PF02771: Acyl-CoA_dh_N" amino acids 4 to 118 (115 residues), 124.2 bits, see alignment E=6.5e-40 PF02770: Acyl-CoA_dh_M" amino acids 122 to 217 (96 residues), 91.2 bits, see alignment E=7.5e-30 PF00441: Acyl-CoA_dh_1" amino acids 229 to 376 (148 residues), 150.7 bits, see alignment E=7.2e-48 PF08028: Acyl-CoA_dh_2" amino acids 247 to 359 (113 residues), 66.8 bits, see alignment E=4.8e-22

Best Hits

Swiss-Prot: 51% identical to IVD_CAEEL: Probable acyl-CoA dehydrogenase 6 (acdh-6) from Caenorhabditis elegans

KEGG orthology group: K11731, citronellyl-CoA dehydrogenase [EC: 1.3.99.-] (inferred from 92% identity to maq:Maqu_2805)

MetaCyc: 80% identical to citronellyl-CoA dehydrogenase (Pseudomonas aeruginosa PAO1)
1.3.8.-

Predicted SEED Role

"Citronellyl-CoA dehydrogenase"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.-

Use Curated BLAST to search for 1.3.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PIQ3 at UniProt or InterPro

Protein Sequence (386 amino acids)

>HP15_2539 acyl-CoA dehydrogenase domain protein (Marinobacter adhaerens HP15)
MKFTAEHEALRKTVRDFVEKEINPHCDEWEAAGEFPIHELFKKLGNLGILGIQKPEEYGG
MGLDYSYNLVAAEELGMAHCGGVPLAIGVQTDMCTPAISRFGSDELKRSFLAPAIAGDMV
GCIGVSEVGAGSDVAGMKTTARKDGDDYIINGSKMWITNSPKSDFICLLANTSDDKPHKN
KSLIIVPTKTPGISFSPHLNKLGMRSSETAQIFFDDVRVPQRYRIGAEGTGFMMQMLQFQ
EERIWGAANVIKALENCITKTIEYCRERKTFGQPLIDNQVIHFRLAELQTEVEALRALTY
QACELHVEGKDVTRLASMAKLKAGRLGREVTDSCLQYWGGNGYMWDNPISRAHRDVRLVS
IGGGADEIMLGIICKMMGTLPGKKRD