Protein Info for HP15_2479 in Marinobacter adhaerens HP15

Annotation: acyl-CoA dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 623 transmembrane" amino acids 541 to 561 (21 residues), see Phobius details PF02771: Acyl-CoA_dh_N" amino acids 92 to 182 (91 residues), 49.8 bits, see alignment E=1e-16 PF02770: Acyl-CoA_dh_M" amino acids 187 to 295 (109 residues), 51.5 bits, see alignment E=2.3e-17 PF00441: Acyl-CoA_dh_1" amino acids 306 to 474 (169 residues), 70.7 bits, see alignment E=3.9e-23 PF12806: Acyl-CoA_dh_C" amino acids 491 to 617 (127 residues), 136.2 bits, see alignment E=1.7e-43

Best Hits

KEGG orthology group: K00257, [EC: 1.3.99.-] (inferred from 92% identity to maq:Maqu_2750)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7, 1.3.99.-

Use Curated BLAST to search for 1.3.8.7 or 1.3.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHV5 at UniProt or InterPro

Protein Sequence (623 amino acids)

>HP15_2479 acyl-CoA dehydrogenase family protein (Marinobacter adhaerens HP15)
MSEQTQGQKLSNLIQLSPRTEVDSMPEYKAPLRDIKFVMTELLNSEQHYANLEGAEDATP
DMVDAIIGEGAKFCEQVLSPLNQVGDKEGCTWSEDGVKTPTGFKEAYQQYVEGGWPSMTA
DPNYGGQGLPHSLGLVMSEMVGTANWSFGMYPGLSHGATNTIEEHGTEEQKQTYLTKLIS
GEWTGTMCLTEPHCGSDLGTLRTKAEPNADGTYAITGTKIFISAGEHDMAENIVHIVLAR
LPGAPEGTKGISLFIVPKCLPNEDGSAGERNAVSCGSIEHKMGIHGNATCVMNFDGAKGW
LIGPENKGLNCMFTFMNTARIGTAIQGLGAAELGFQGSLAYAKERLAMRSLSGPKNPEGI
ADPIIVHPDVRRMLLTQKAVAEGARALIYLTAQQADVVHSGKTEEERKAADEALGFLTPI
AKAFLTEIGYEAANLGMQVFGGHGFISEWGMEQNVRDARIGMIYEGTTGIQALDLLGRKV
LMTQGESLKGFTKQVHLFCKENAEDEQLKEFIEPLAAMNKEWGELTTKIGMSAMKNREEV
GAASVDYLMYSGYAVFAYLWARMAKVALDKMVEGTTEEMFYNAKIQTARFYFKRMLPRAK
GHAESMLAGADSLMDMPEEAFAI