Protein Info for HP15_2467 in Marinobacter adhaerens HP15

Annotation: PhoH family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 327 PF02562: PhoH" amino acids 115 to 317 (203 residues), 321.3 bits, see alignment E=3.5e-100 PF13604: AAA_30" amino acids 119 to 270 (152 residues), 28.9 bits, see alignment E=1.4e-10 PF13245: AAA_19" amino acids 121 to 270 (150 residues), 27.5 bits, see alignment E=4.6e-10

Best Hits

Swiss-Prot: 58% identical to PHOL_ECO57: PhoH-like protein (ybeZ) from Escherichia coli O157:H7

KEGG orthology group: K06217, phosphate starvation-inducible protein PhoH and related proteins (inferred from 93% identity to maq:Maqu_2739)

Predicted SEED Role

"Phosphate starvation-inducible protein PhoH, predicted ATPase" in subsystem Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHU3 at UniProt or InterPro

Protein Sequence (327 amino acids)

>HP15_2467 PhoH family protein (Marinobacter adhaerens HP15)
MNANDHRQFDLHPVDQRRLATLCGQFDENLKMIEKRLHVKVGRRGHHIRVEGETEHVAAA
VEVIRHLYRETEATDDLPPDTVHLYIRETGFERLPEDVPYDGAVTVIKTPKLQAKPRGAN
QQKYVHNIRTHDINFGIGPAGTGKTWLAVACAVEALKDEQVKRILLVRPAVEAGEKLGFL
PGDLAQKVDPYLRPLYDALYEMLGFDQVTRLIEKSVIEIAPLAFMRGRTLNNSFIILDES
QNTTREQMKMFLTRIGFGSTAVITGDTTQVDLPRGQNSGLIHAAGVLSKVSGIGFTRFEA
KDVVRHPLVQRIVEAYDSFDDGSATGQ