Protein Info for HP15_2437 in Marinobacter adhaerens HP15

Annotation: KpsF/GutQ family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 325 PF01380: SIS" amino acids 43 to 173 (131 residues), 90.8 bits, see alignment E=6.5e-30 TIGR00393: sugar isomerase, KpsF/GutQ family" amino acids 47 to 315 (269 residues), 326.9 bits, see alignment E=5.3e-102 PF00571: CBS" amino acids 202 to 258 (57 residues), 27.7 bits, see alignment E=2.8e-10 amino acids 270 to 322 (53 residues), 39.6 bits, see alignment 5.3e-14

Best Hits

Swiss-Prot: 60% identical to KDSD_PSEAE: Arabinose 5-phosphate isomerase KdsD (kdsD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K06041, arabinose-5-phosphate isomerase [EC: 5.3.1.13] (inferred from 77% identity to maq:Maqu_2710)

MetaCyc: 53% identical to D-arabinose 5-phosphate isomerase KdsD (Escherichia coli K-12 substr. MG1655)
Arabinose-5-phosphate isomerase. [EC: 5.3.1.13]

Predicted SEED Role

"Arabinose 5-phosphate isomerase (EC 5.3.1.13)" in subsystem KDO2-Lipid A biosynthesis (EC 5.3.1.13)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHR3 at UniProt or InterPro

Protein Sequence (325 amino acids)

>HP15_2437 KpsF/GutQ family protein (Marinobacter adhaerens HP15)
MTEQTAHDFRSSAIRAIRIERDAIDALESRIDDQFTRACEVIMNCTGRVVVTGMGKSGHI
GNKIAATLASTGTPSFSCIPEKQATATWGITPQDVVIAISNSGNTSEVVTILPLIKRMGA
PLISMTGNATSTLAREAVANLDVSVMVEACPLGLAPTSSTTATLVMGDALAVALLEARGF
SAEDFAFSHPGGSLGRRLLLRVSDIMHTGDQIPVVNEGTPLSGALLEISRKGLGMTTVVN
GEGTLTGIFTDGDLRRTLDRSVDIHHTPINEVMTRNGKTIQADHLAAEALNIMEEMKINA
LPVTNDSGALIGAINMHDLLRAGVI