Protein Info for PGA1_c25230 in Phaeobacter inhibens DSM 17395

Annotation: protein TyrC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07991: IlvN
  • amino acids 8 to 96 (89 residues), 21.3 bits, E=4.3e-08
• PF03807: F420_oxidored
  • amino acids 8 to 91 (84 residues), 41.1 bits, E=5.8e-14
• PF03446: NAD_binding_2
  • amino acids 8 to 113 (106 residues), 35.7 bits, E=2.3e-12
• PF02153: PDH_N
  • amino acids 21 to 174 (154 residues), 136.8 bits, E=1.1e-43
• PF20463: PDH_C
  • amino acids 179 to 279 (101 residues), 92.4 bits, E=5e-30

Best Hits

KEGG orthology group: K00220, cyclohexadieny/prephenate dehydrogenase [EC: 1.3.1.12 1.3.1.43] (inferred from 86% identity to sit:TM1040_2100)

Predicted SEED Role

"Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.12, EC 1.3.1.43)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis III (3/4 steps found)
• 4-hydroxy-3-prenylbenzoate biosynthesis (1/4 steps found)
• superpathway of chorismate metabolism (36/59 steps found)
• superpathway of novobiocin biosynthesis (4/19 steps found)

KEGG Metabolic Maps

• Novobiocin biosynthesis
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.3.1.12, 1.3.1.43

Use Curated BLAST to search for 1.3.1.12 or 1.3.1.43

Sequence Analysis Tools

See I7EZ59 at UniProt or InterPro

Protein Sequence (306 amino acids)

>PGA1_c25230 protein TyrC (Phaeobacter inhibens DSM 17395)
MSAPIYNRIALIGLGLIASSMAHAIRRGGLASEITGYARSAETRDTARRINLCDRVCDTA
AEAAQDADLIVLCVPVGAMDAVMADIAPVLKPGATVSDVGSVKRHVIDAVQPHIPEGVHF
VPAHPLAGTEHSGPEAGFAELYDNRWCLLVPVEGSDRAPVDRLRQLWEGMGANVDEMDAD
HHDLVLAVTSHAPHLIAYTMVGVADDLRRVTDSEVIKYSAAGFRDFTRIAASDPTMWRDV
FLTNKDATLEILGRFTEELFALQRAIRTGDGEHLHQYFTRTRAIRRGIIEAGQDTAAPNF
GRETKS