Protein Info for PGA1_c25150 in Phaeobacter inhibens DSM 17395

Annotation: ATP-dependent Clp protease ATP-binding subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 773 TIGR02639: ATP-dependent Clp protease ATP-binding subunit ClpA" amino acids 5 to 744 (740 residues), 1111.9 bits, see alignment E=0 PF02861: Clp_N" amino acids 15 to 63 (49 residues), 44.5 bits, see alignment 1.2e-14 PF00004: AAA" amino acids 221 to 351 (131 residues), 49.2 bits, see alignment E=6.6e-16 amino acids 502 to 617 (116 residues), 46.9 bits, see alignment E=3.2e-15 PF17871: AAA_lid_9" amino acids 360 to 463 (104 residues), 96.4 bits, see alignment E=7.5e-31 PF07724: AAA_2" amino acids 496 to 656 (161 residues), 202 bits, see alignment E=5.7e-63 PF00158: Sigma54_activat" amino acids 500 to 622 (123 residues), 21.7 bits, see alignment E=1.2e-07 PF07728: AAA_5" amino acids 502 to 619 (118 residues), 52.1 bits, see alignment E=6.1e-17 PF10431: ClpB_D2-small" amino acids 663 to 743 (81 residues), 87.5 bits, see alignment E=4.1e-28

Best Hits

Swiss-Prot: 84% identical to CLPA_RHOBL: ClpA homolog protein from Rhodobacter blasticus

KEGG orthology group: K03694, ATP-dependent Clp protease ATP-binding subunit ClpA (inferred from 88% identity to dsh:Dshi_2939)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpA" in subsystem Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E367 at UniProt or InterPro

Protein Sequence (773 amino acids)

>PGA1_c25150 ATP-dependent Clp protease ATP-binding subunit (Phaeobacter inhibens DSM 17395)
MPSFSSTLEQAIHAALALANERRHEFATLEHLLLALLDEPEAARVMRACSVDLTELRATL
VEFVDEDLANLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERES
DAAYFLQDQDMTRYDAVNFIAHGVAKDPAFGESRPVSGSPEVEDEPQPTTEGDKKESALA
KYCVDLNEKSREGDIDPLIGRSHEVERCIQVLCRRRKNNPLLVGDPGVGKTAIAEGLARK
IVAGETPEVLSETTIYSLDMGALLAGTRYRGDFEERLKAVVTELEDHPDAVLFIDEIHTV
IGAGATSGGAMDASNLLKPALQGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPS
VEDSIEILKGLKPYFEDHHGIRFTSDAIKSAVELSARYINDRKLPDKAIDVIDEAGAAQH
LVVESKRRKTIGVKEIEAVVAKIARIPPKNVSKDDAEVLKDLERSLKRVVFGQDAAIDAL
SSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAV
SRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDVFNILLQVMDNGQLTDHN
GRTVNFRNVVLIMTSNAGASEQAKAAIGFGRDRREGEDTAAIERTFTPEFRNRLDAVISF
APLPKDVILQVVEKFVLQLEAQLMDRNVSIELTRKAAEWLADKGYDDRMGARPLGRVIQE
HIKKPLAEELLFGKLAKGGLVKVGIKDGKLDLRIEGPAKPRISGDKPPLLTAE