Protein Info for HP15_2383 in Marinobacter adhaerens HP15

Annotation: nucleotide sugar epimerase/dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 38 to 59 (22 residues), see Phobius details amino acids 70 to 90 (21 residues), see Phobius details PF13727: CoA_binding_3" amino acids 25 to 194 (170 residues), 41.9 bits, see alignment E=4.1e-14 PF04321: RmlD_sub_bind" amino acids 238 to 368 (131 residues), 32.4 bits, see alignment E=1.9e-11 PF08659: KR" amino acids 239 to 365 (127 residues), 25 bits, see alignment E=5.7e-09 PF02719: Polysacc_synt_2" amino acids 239 to 532 (294 residues), 412.3 bits, see alignment E=3.7e-127 PF01370: Epimerase" amino acids 239 to 441 (203 residues), 64.9 bits, see alignment E=2.8e-21 PF16363: GDP_Man_Dehyd" amino acids 240 to 367 (128 residues), 40.6 bits, see alignment E=8.1e-14 PF01073: 3Beta_HSD" amino acids 240 to 372 (133 residues), 28.1 bits, see alignment E=3.8e-10

Best Hits

KEGG orthology group: None (inferred from 71% identity to maq:Maqu_2611)

Predicted SEED Role

"Nucleoside-diphosphate sugar epimerase/dehydratase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PH44 at UniProt or InterPro

Protein Sequence (602 amino acids)

>HP15_2383 nucleotide sugar epimerase/dehydratase (Marinobacter adhaerens HP15)
MPDRGQLIVSGLTVAITIAVFVKLGLYRAVIRYLSDRAFITVITGVFVSAITLILLGYWL
EVLVPRSVPIIYGALAFIFVSGTRMTVRMLVNRPKHNNKQYVGIVGAGETGLQLANALDQ
GTEYHPCAFISLLKANHRALVNGIPVYDISHIERVVKDHRIKRLLLALDADSGIDRKRLL
KRLEPLAIPVQTVPTMSELVAGQARINDIRDLEIEDLLGRDPVQPDNAQVAASLYNRSVL
VTGAGGSIGSELCRQIIRHRPARLVLFEQSEFSLYAIERELQALNSIEGLGVEINPLLGS
VTHRRRCETVMRSFGIETVYHAAAYKHVPLVEHNVIEGVQNNVFGTFHVAEAAIAAGVQR
FVLISTDKAVRPTNVMGASKRMAELVLQGLAQRQSGTIFSMVRFGNVLGSSGSVVPLFRD
QIRDGGPVTVTHPDIIRYFMTIPEASQLVLQAGSMGQGGEVFVLDMGEPVKIADLARKMI
HLMGLLEKTDDRPDGDIEIVFSGLRPGEKLYEELLIGDNPQGTAHPRIMMAREASMPWEE
VEQTLNGLIRASHEFDCQGIVDILKNAPTGFSPNGSVADLVWCNGAKDVIPFQVEKVRQL
HQ