Protein Info for PGA1_c24670 in Phaeobacter inhibens DSM 17395

Annotation: thymidine kinase Tdk

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00265: TK
  • amino acids 3 to 186 (184 residues), 164.1 bits, E=1.5e-52

Best Hits

Swiss-Prot: 81% identical to KITH_RUEPO: Thymidine kinase (tdk) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: K00857, thymidine kinase [EC: 2.7.1.21] (inferred from 81% identity to sil:SPO0914)

MetaCyc: 53% identical to thymidine/deoxyuridine kinase (Escherichia coli K-12 substr. MG1655)
Deoxynucleoside kinase. [EC: 2.7.1.145, 2.7.1.21]; 2.7.1.145,2.7.1.21 [EC: 2.7.1.145, 2.7.1.21]

Predicted SEED Role

"Thymidine kinase (EC 2.7.1.21)" in subsystem Folate Biosynthesis (EC 2.7.1.21)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleoside salvage (8/9 steps found)
• pyrimidine deoxyribonucleosides salvage (4/5 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.145 or 2.7.1.21

Sequence Analysis Tools

See I7DSV0 at UniProt or InterPro

Protein Sequence (199 amino acids)

>PGA1_c24670 thymidine kinase Tdk (Phaeobacter inhibens DSM 17395)
MAKLYFHYSTMNAGKSTVLLQASHNYRENNMDTYLLTAALDDRAGQGRIASRIGIGAEAD
MFRPGENLYDKVSNRLAKGAVASIFVDEAQFLSPDQVWDLARVVDDLRVPVLCYGLRVDF
QGKLFPGSATLLALADEMREVRTICHCGKKATMVIRQDDQGRTITEGAQVQIGGNETYVS
LCRRHWRQATGDLPAEASD