Protein Info for PGA1_c24340 in Phaeobacter inhibens DSM 17395

Annotation: phosphomannomutase/phosphoglucomutase AlgC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 25 to 154 (130 residues), 86.4 bits, E=2.9e-28
• PF02879: PGM_PMM_II
  • amino acids 173 to 271 (99 residues), 87.5 bits, E=1.6e-28
• PF02880: PGM_PMM_III
  • amino acids 277 to 389 (113 residues), 46.2 bits, E=9.5e-16
• PF00408: PGM_PMM_IV
  • amino acids 425 to 486 (62 residues), 31.9 bits, E=2.2e-11

Best Hits

KEGG orthology group: K01835, phosphoglucomutase [EC: 5.4.2.2] K01840, phosphomannomutase [EC: 5.4.2.8] (inferred from 89% identity to sit:TM1040_0652)

Predicted SEED Role

"Phosphoglucosamine mutase (EC 5.4.2.10) / Phosphomannomutase (EC 5.4.2.8)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis or Alginate metabolism or Mannose Metabolism (EC 5.4.2.10, EC 5.4.2.8)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• colanic acid building blocks biosynthesis (9/11 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (5/6 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• GDP-mannose biosynthesis (2/4 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (1/3 steps found)
• chitin biosynthesis (5/9 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• sucrose biosynthesis II (4/8 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (1/4 steps found)
• starch degradation III (1/4 steps found)
• starch degradation V (1/4 steps found)
• peptidoglycan recycling I (8/14 steps found)
• glycogen degradation II (2/6 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• glycogen degradation I (3/8 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (7/14 steps found)
• β-(1,4)-mannan degradation (1/7 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (1/8 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• starch biosynthesis (2/10 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (7/19 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (14/33 steps found)
• streptomycin biosynthesis (2/18 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.10, 5.4.2.8

Use Curated BLAST to search for 5.4.2.10 or 5.4.2.2 or 5.4.2.8

Sequence Analysis Tools

See I7E2Y8 at UniProt or InterPro

Protein Sequence (498 amino acids)

>PGA1_c24340 phosphomannomutase/phosphoglucomutase AlgC (Phaeobacter inhibens DSM 17395)
MTKPIPEVRPNTWSFLRDPMITPTGFREYDARWKYPEEINLPGMTALGLGLGTQMHKRGI
PPVIAVANDYRDYSVAIKHALIIGLMQAGIEVRDIGPALSPMAYFAQFHLDVPAVAMVTA
SHNPNGWTGVKMGFERPLTHGPDEMGELRDIVLNGEGVARPGGSYQFVDGVKEAYLDDLV
GDFKMSRPLKVVCATGNGTASAFAPELFERMGVEVVDSHNALDYTFPHYNPNPEAMEMLH
DMSASVKASGADMALGFDGDGDRCGVVDDEGEEIFADKVGVIMARDLSKLYPNSTFVADV
KSTGLFASDPELKANGVTADYWKTGHSHMKRRVKEIGALAGFEKSGHYFLAEPVGRGYDC
GMRVAVEICKLMDRNPDKSMSDLRKALPKTWATPTMSPYCADTEKYTVLERLVAKLVAKA
EAGETLADRPIKEVVTVNGARVILDNGSWGLVRASSNTPNLVVVCESSESEAELREIFAE
IDAVIRTEPLVGEYDQTF