Protein Info for HP15_237 in Marinobacter adhaerens HP15

Annotation: HemY domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 413 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 43 to 63 (21 residues), see Phobius details TIGR00540: heme biosynthesis-associated TPR protein" amino acids 3 to 393 (391 residues), 319.8 bits, see alignment E=1.1e-99 PF07219: HemY_N" amino acids 27 to 132 (106 residues), 102 bits, see alignment E=3e-33

Best Hits

KEGG orthology group: K02498, HemY protein (inferred from 84% identity to maq:Maqu_0484)

Predicted SEED Role

"Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PK70 at UniProt or InterPro

Protein Sequence (413 amino acids)

>HP15_237 HemY domain protein (Marinobacter adhaerens HP15)
MIRLLLIVLLALLIGTGLSLGLQYDLGYIRISLGHYLIETNFWVGLGLIVALIVLTVLTI
NLIRRLRTSTGLVAGWIARGNERRARRRTTQGLLALAEGNWPRARKLLTSSASHADTPLI
NYLAAAQASFETGDHEAVDDLLRKAFDSTPGSDMAVGITQAQLQLAGNRLEQALATLVRL
RKQSPHHPFVLKLLKNTYLRLEDWRELSRLLPELRKRSVLSEAELNDLERQVWHNLLERA
AEDCRRQQKQDPEASLEPLTRLWDELPGFLRRDEYTIRDYARLLASLGDEVQTETLLRKV
LRNHWSDELINLYGRVKGQKPDEQLLLAEQWLKDRPNNPELLLALGRLSLRNELWGKARE
YFETSLRLKRSREALAELSRLNAHMGEEEASVKLLMQGLAKDNGLPELPMPRA