Protein Info for HP15_2307 in Marinobacter adhaerens HP15

Annotation: xanthine/uracil permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 418 transmembrane" amino acids 13 to 34 (22 residues), see Phobius details amino acids 42 to 74 (33 residues), see Phobius details amino acids 87 to 106 (20 residues), see Phobius details amino acids 116 to 137 (22 residues), see Phobius details amino acids 156 to 174 (19 residues), see Phobius details amino acids 181 to 201 (21 residues), see Phobius details amino acids 222 to 245 (24 residues), see Phobius details amino acids 304 to 325 (22 residues), see Phobius details amino acids 331 to 353 (23 residues), see Phobius details amino acids 365 to 381 (17 residues), see Phobius details amino acids 386 to 403 (18 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 8 to 400 (393 residues), 375 bits, see alignment E=2.4e-116 PF00860: Xan_ur_permease" amino acids 12 to 381 (370 residues), 331 bits, see alignment E=4.3e-103

Best Hits

Swiss-Prot: 58% identical to URAA_PASMU: Probable uracil permease (uraA) from Pasteurella multocida (strain Pm70)

KEGG orthology group: K02824, uracil permease (inferred from 89% identity to maq:Maqu_1980)

Predicted SEED Role

"Uracil permease" in subsystem De Novo Pyrimidine Synthesis or Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PGG0 at UniProt or InterPro

Protein Sequence (418 amino acids)

>HP15_2307 xanthine/uracil permease (Marinobacter adhaerens HP15)
MQDHNNDPVWKQAIAGSQMLLVAFGALVLMPLITGLDPNVALFTAGLGTLIFHVVTGGQI
PIFLASSFAFIAPVIASKGKFGMEETLGGLMAAGILYIFLSGLVRLRGTGFVRRLLPPVV
IGPVIMTIGLGLAPVAVHMASGRTGDGANQLIPYDTAIWIAMISLAVTIIMSVWSKGIFR
LIPIMFGVITGYILSAFAGIVDTTPIRDAAWFAVPNFVAPEFSWGAVLFMIPVAIAPAIE
HIGDVLAIGNVTRKNYLEKPGLHRTLLGDGLATSAASMLGGPPNTTYSEVTGAVMLTKNF
NPKVMWWAACIAIVLAFVGKFGAALQTIPVPVMGGILCLLFGSIAVVGLNTLIRHQVDLS
QSRNLVIVGVTLVFGIGGMVLGHLEGIALCAVAAIILNLILPGSREAWGKAVYEQKAD