Protein Info for HP15_2298 in Marinobacter adhaerens HP15

Annotation: chemotaxis histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 716 PF01627: Hpt" amino acids 8 to 106 (99 residues), 63.9 bits, see alignment E=2.6e-21 PF02895: H-kinase_dim" amino acids 333 to 392 (60 residues), 60.7 bits, see alignment 3e-20 PF02518: HATPase_c" amino acids 439 to 579 (141 residues), 66.9 bits, see alignment E=4.1e-22 PF01584: CheW" amino acids 586 to 714 (129 residues), 90.3 bits, see alignment E=1.8e-29

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 79% identity to maq:Maqu_1972)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PGF1 at UniProt or InterPro

Protein Sequence (716 amino acids)

>HP15_2298 chemotaxis histidine kinase (Marinobacter adhaerens HP15)
MAFDADEEILQDFLVEAGEILEKLSEQLVDLERHPDDSDLLNAIFRGFHTVKGGAGFLQL
EALVNCCHSAENVFDILRNHKRKVDSELMDVVLEALDYVNAMFEQVRNHEELTPAPDELI
ARLDALAQPEGEGAPATAAQPEQEESEPAEDGGDITDDEFEQLLDALQDEKSAEVSSASS
AGSAGGDQESSGDDEITDDEFEALLDQLHGKGQFAGAPAGEEEASSKEEKPAAKAGSAGG
DDLITDDEFEKLLDDLHGKGGSPTAGGEPSASKEPAAPKQPSAPKQPASSKEPASPKANT
SKPEKSKPAERPEAKGAAAPAMPARENAPAAETTVRVDTKRLDDIMNMVGELVLVRNRLQ
RLGAESEDEHMHKAVSNLDVVTTDLQSAVMQTRMQPIKKVFGRFPRVVRDLARNLKKEVN
LVMHGEETDLDKNLVEALSDPLVHLVRNSVDHGIEAPEVREKAGKPRQGTVTLSAEQEGD
HILLFIEDDGAGMDPEVLRRKAVEKGIYDQDAADRLTNSECYNLIFAAGFSTKEQISDVS
GRGVGMDVVKTKIGQLNGQLSIESELGKGSRIVIKVPLTLAIMPTLMIMLGDQSFALPLV
NVVEIFHLDLTKTNIVDGRECIVVRDKVFPLFHIKRWLVRGGAGQEVPDNAHVVIVAMGT
KQVGFVVDQLVGQEEVVIKPLGRALQGTPGMAGATITGDGRIALIIDVPSLLQHYG