Protein Info for PGA1_c23720 in Phaeobacter inhibens DSM 17395

Annotation: glutathione reductase Gor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 451 TIGR01424: glutathione-disulfide reductase" amino acids 3 to 445 (443 residues), 639.5 bits, see alignment E=1.2e-196 PF07992: Pyr_redox_2" amino acids 5 to 317 (313 residues), 228.5 bits, see alignment E=4.4e-71 PF13738: Pyr_redox_3" amino acids 9 to 301 (293 residues), 50.6 bits, see alignment E=6.1e-17 PF00070: Pyr_redox" amino acids 170 to 241 (72 residues), 66.5 bits, see alignment E=9e-22 PF01593: Amino_oxidase" amino acids 214 to 260 (47 residues), 22.1 bits, see alignment 3e-08 PF02852: Pyr_redox_dim" amino acids 337 to 444 (108 residues), 121.3 bits, see alignment E=7.6e-39

Best Hits

Swiss-Prot: 51% identical to GSHR_BURCE: Glutathione reductase (gor) from Burkholderia cepacia

KEGG orthology group: K00383, glutathione reductase (NADPH) [EC: 1.8.1.7] (inferred from 88% identity to sit:TM1040_1957)

Predicted SEED Role

"Glutathione reductase (EC 1.8.1.7)" in subsystem Glutathione: Redox cycle (EC 1.8.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.7

Use Curated BLAST to search for 1.8.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EYS9 at UniProt or InterPro

Protein Sequence (451 amino acids)

>PGA1_c23720 glutathione reductase Gor (Phaeobacter inhibens DSM 17395)
MSFDYDLFVIGGGSGGVRAARVAAQRGVKVALAEEDRYGGTCVIRGCVPKKLMVFASEYA
GMVEDAQAYGWDLSPGSFDWDRFKTKLHAELDRLEGIYRNILKNNEVETFDQRAKLADAH
TVELADGTRKTAKHILIATGGWPVTPEFPGSELAITSNEIFHLEKLPETMLIVGGGYIAC
EFAGIMNGLGVKTTQYYRGAQILRGFDDEARGLISEEMCQSGVDLHLGTNVLEMRKEGDK
IWVKATNGDENLFDQVMFATGRAPNADGLGLEELGIERDRAGAIVVDQYSQTGVPSVYAV
GDVTNRVNLTPVAIREGMAFVETVFAGNPTSPDHELIPTAIFTQPEMGTVGLSEEAAAEQ
EEIEVYATSFKPMQQAFAGRAERVLMKLIVSKATRKVLGCHIVAPGAGEMIQLAGIAVKM
GATKEDFDRTVAVHPTMSEELVTMKTPVRTA