Protein Info for HP15_2274 in Marinobacter adhaerens HP15

Annotation: TPR repeat-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 604 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 63 to 82 (20 residues), see Phobius details amino acids 95 to 111 (17 residues), see Phobius details amino acids 312 to 340 (29 residues), see Phobius details PF13519: VWA_2" amino acids 96 to 203 (108 residues), 52.3 bits, see alignment E=1.6e-17 PF13432: TPR_16" amino acids 383 to 437 (55 residues), 35.4 bits, see alignment 2.4e-12 PF07719: TPR_2" amino acids 406 to 437 (32 residues), 25.1 bits, see alignment (E = 2.6e-09)

Best Hits

KEGG orthology group: K07114, uncharacterized protein (inferred from 61% identity to maq:Maqu_1949)

Predicted SEED Role

"TPR domain protein in aerotolerance operon"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PFW8 at UniProt or InterPro

Protein Sequence (604 amino acids)

>HP15_2274 TPR repeat-containing protein (Marinobacter adhaerens HP15)
MWADFHFLRPLWLLLILLIPILYLAFRQLRMGDSGWSRLIPARLLSPLIRHNGSSGQSNK
SPLVPASLALIILSLALAGPAWREAPTPLKQPGDSLVIALDLSLSMLATDVEPDRLTRAK
RKIRDILELREGSLTGLLVFSGDAHVVTPLTDDSRTIEGMLNVLDPVIMPATGNRADLAV
ARAKALLEQGAPGEGRILLITDSLNDDYEGTIRDTLSGTGYALNTLVVGTENGGPIPLAR
RGFIRENGDIVISRAEPEALAALARSSGGQSHELTLDDTDIEALDLSPRDSDDWQDSEDG
LTVNRWQDDGYWLLWLALPLVLMGWRRGALSALALILLPVWPQPAAAISWEELWQREDQR
APALIQDNPESAARQLEDPEWRGSALYRSGKFDSAAEAFARKQGPRASYNRGNALARAGK
LEEALAAYDAALNAAPDMEDALHNRKIVEELLNQEQQNQDGNQDNNQQESRNSQGDGSNQ
QQNRQGQNGNNESENPGSQGNSQQQNPENNESSSDTENQQGGQTAEQNQQQAGERGDPEQ
ASGEQETPSGQSPAPAPISETPLTQSQEQWLRRVPDNPGGLLQRKFLQQYQQRQTPSDEG
DTPW