Protein Info for PGA1_c22850 in Phaeobacter inhibens DSM 17395

Annotation: type IV secretion system protein VirB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 788 PF03135: CagE_TrbE_VirB" amino acids 184 to 378 (195 residues), 105.5 bits, see alignment E=3.9e-34

Best Hits

KEGG orthology group: K03199, type IV secretion system protein VirB4 (inferred from 71% identity to dsh:Dshi_3976)

Predicted SEED Role

"ATPase provides energy for both assembly of type IV secretion complex and secretion of T-DNA complex (VirB4)" in subsystem Type 4 secretion and conjugative transfer or pVir Plasmid of Campylobacter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E2J8 at UniProt or InterPro

Protein Sequence (788 amino acids)

>PGA1_c22850 type IV secretion system protein VirB (Phaeobacter inhibens DSM 17395)
MLRDPSDDLAMLPDWARKERPMASMLPYVSLVNDVTIRTRGNALFQCIRIDGVNSMTSDD
AHLEKIRALFAAIVAQIGPEYSFYVHKVSKAIETTLPPMSNEGFAQALDTRWQAAMARAG
LRDKTLTLTVLKRPPLGARLRLKRSDSIAQLKEQTAKQLRKLSEVVGFLLSSFTEMNPRL
LGAESGELLGFLGALNIGQERPLFAKSRFGIIAEDVANTRVTFQGRGFTLDDGAAGKRYG
TSFAIKTYPAKTNCTMFDELNLPVDMVVTHSFTPINSNIMASRIKRQQRLMKASDDGAIS
LAEELVDALDDLESKRLSFGDHHMTVTVFAETEERLEAIAAEVRNIAASEGVNLVNESFA
ARTHYFAQHPGNGQMRSRKAAITNTNFADLAALHRGQLGKSGDRVPWGKPISLFPTPERS
GFLFNYHETGQPDKEPTGGHTLILGRPGSGKSVLSAFLMTQARRCDARVFVFDYRAGMEM
AVRANGGRYSAIKAGEATGLNPLRTEIDGRGQTWLSDWLATLLLRTDKPLSPVQINRIQE
VVRQNAGASDAALRNWRDLASLFVAGADEGDLFERIQEWTADGRYGWIFGQSVEDTFSLE
GDVVGFDLTGILDSESEKERMAVLSYLFRRVERVIEDRKPTLIIIDEAWKALDNPYFADR
LSNWLVTARKQNAVVVMMTQYASQLEKTRTGKTIIEAVPTQLLLPNIRASASDYTMLGLA
EKELSVLLGTGSNSRLALVRDDQGSVVIDTDLSALGPYLTILGGMEKGEALVGADYRQNP
DFWRQIDA