Protein Info for PGA1_c02360 in Phaeobacter inhibens DSM 17395

Annotation: pyridine nucleotide-disulphide oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 PF07992: Pyr_redox_2" amino acids 13 to 322 (310 residues), 219 bits, see alignment E=4.8e-68 PF01134: GIDA" amino acids 13 to 75 (63 residues), 29.4 bits, see alignment E=2.3e-10 PF12831: FAD_oxidored" amino acids 13 to 119 (107 residues), 43.9 bits, see alignment E=1.1e-14 PF13738: Pyr_redox_3" amino acids 15 to 306 (292 residues), 65.9 bits, see alignment E=1.9e-21 PF00070: Pyr_redox" amino acids 174 to 244 (71 residues), 61.5 bits, see alignment E=4.6e-20 PF02852: Pyr_redox_dim" amino acids 342 to 439 (98 residues), 27.3 bits, see alignment E=1.7e-09

Best Hits

Predicted SEED Role

"Glutathione reductase (EC 1.8.1.7)" in subsystem Glutathione: Redox cycle (EC 1.8.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.7

Use Curated BLAST to search for 1.8.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DLF4 at UniProt or InterPro

Protein Sequence (442 amino acids)

>PGA1_c02360 pyridine nucleotide-disulphide oxidoreductase (Phaeobacter inhibens DSM 17395)
MSHLTHPPAASHDLVVIGGGSGGLAAAKAAARLGASVVMIERAELGGTCVNRGCTPKKLM
WSAAAQQQSLREMAKVGLIDRPHLDFAALRRRSDAKIDRLNRHFEEELQQAGVRLLRATA
EIGEAGQVHAGGDVFQPGKLLLATGARPRALDIPGGDLAVTSDDVFHWTDLPGRLLIIGG
GYIGCEFASIFAALGSEVQLMTDSDRLLEQFHAPAVDCVQAGLEKQGVTIEFGCKPVQID
FNGTMFKVSFDDGSIQYADRVIAAIGRVPNTDNMGPGLQGIAHANTGALAIDEHFQTSIP
GIYAIGDVADRLPLTPVSTRDGACFAAQHFGAGADQINLDLVPQSAYTIPPVAQVGSMSE
GQDDGEVIANLASDVLDDGTAANSFVARAICDGRLSGIALVNHAAPEMIAPFAALLASGA
SADDLAAVTGVHPSFGEETVGP