Protein Info for HP15_2140 in Marinobacter adhaerens HP15

Annotation: tetratricopeptide TPR_2 repeat protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 947 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF13432: TPR_16" amino acids 402 to 459 (58 residues), 20.8 bits, see alignment 2.2e-07 PF13174: TPR_6" amino acids 429 to 458 (30 residues), 19.1 bits, see alignment (E = 8e-07) amino acids 713 to 743 (31 residues), 14.4 bits, see alignment (E = 2.5e-05)

Best Hits

KEGG orthology group: None (inferred from 92% identity to maq:Maqu_1813)

Predicted SEED Role

"TPR domain protein, putative component of TonB system" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PF24 at UniProt or InterPro

Protein Sequence (947 amino acids)

>HP15_2140 tetratricopeptide TPR_2 repeat protein (Marinobacter adhaerens HP15)
MVGALVMASGCQMLQSMMPAGGEEMPRVREGTLAALPAIETRQESADAAAVSDPAEDVSI
ETVMDSYKALLPLVEDPRKQVTIRHRLADLEFQRAERKMADSAVDELSGAIDAYQRLLSE
YPEREGNDQIYYQLARAWELRGATPQQLEALNTLVRRYPDSEYWVEAQFRRGDLLFIDGR
YGEAEQAFDEVTLASQERMADPSFLVNAHYMKGWSLFKQAQYQEALFSYVEVLDLVMPEG
RPVADVDQRSQTLIEDLFRVVGLSLSYLDGAETLQALFRQTGGRPYEILVYDRYSELLLE
REQYSDAIDVFEAYIEDHPESPWAPRYHIRIIDTLELAGFTRTIPERKAGFVSLYGIYSD
YWQSAGPDAIGFIEQQLEQLLPELADRQYLLAGEAEDDQQADDHYRKAASYYAEFAATFP
DHPRTPERLFLLGETYLELEDWPAAIAAFERVAYDYPEDTVADRAAEAGYASVLAFREYS
QTWESEPVSERMAYQELQQLNRLRFANAFPGDARAPAVYYIALQREFDLNNWEETVNMAA
RLVTWQPTPPDELTTEALLLSGHSLSELARYAEAEQAYRDALATMAEDDERRSGVRENLA
AAVYRQAEQLADAGNVEAAVSEFLRVGTAVPESALRANAEYDAASLLITANLWEQAIGVL
TSFRRSFPNHELIDTVPAKLALAYRETEQWERAADELQQMVSLAKTPEERRENLLIAAEL
YDQAGNREKAIDTWRNYANSHPEPTDVYMEAANRLAELYQEDGDAESRDYWLRKQMETVD
RDPDAADDRMRYLAASASAILARDALARYDGIRLTLPLNQSMTAKTDALERAVNAYKKTA
SYGLSSFATEAGYQIAHIYARLGADLMDSERPTGLSELELAQYELLLEEQAYPFEDNAID
IHEQNIRRAREGIFDEWVKRSYEALKALLPGRYRKEEVTQGVVYELD