Protein Info for HP15_216 in Marinobacter adhaerens HP15

Updated annotation (from data): DNA damage response protein (yhgF like)
Rationale: Conserved and specific phenotype: important for resisting cisplatin. Also important for resisting ionizing radiation in E. coli (PMID:25049088)
Original annotation: transcriptional accessory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 779 PF09371: Tex_N" amino acids 3 to 76 (74 residues), 111.3 bits, see alignment E=5.8e-36 PF22706: Tex_central_region" amino acids 131 to 309 (179 residues), 257.3 bits, see alignment E=3.4e-80 PF16921: Tex_YqgF" amino acids 326 to 451 (126 residues), 169.4 bits, see alignment E=1.8e-53 PF14635: HHH_7" amino acids 465 to 556 (92 residues), 31.7 bits, see alignment E=6.6e-11 PF12836: HHH_3" amino acids 491 to 555 (65 residues), 98.5 bits, see alignment E=7.3e-32 PF17674: HHH_9" amino acids 561 to 630 (70 residues), 82.4 bits, see alignment E=1.4e-26 PF00575: S1" amino acids 649 to 720 (72 residues), 71.4 bits, see alignment E=2.7e-23

Best Hits

KEGG orthology group: K06959, uncharacterized protein (inferred from 88% identity to maq:Maqu_0464)

Predicted SEED Role

"Transcription accessory protein (S1 RNA-binding domain)" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PK49 at UniProt or InterPro

Protein Sequence (779 amino acids)

>HP15_216 DNA damage response protein (yhgF like) (Marinobacter adhaerens HP15)
MNSISRRIAEELGVREQQVNATVELLDEGATVPFIARYRKEITGSLDDSQLRNLEERLRY
LRELEDRRATILKSIEEQGKLTDELKATIQDADTKNRLEDLYLPYKPKRRTKAQIAREAG
LEPLADALYDDPTLDPEITAQGYLNKEAGVEDTKAALDGARYILMERFAEDAELLGSLRD
FIWQEGQLKVTVVEGKENEGAKFRDYFDHVEPLKKVPSHRALAILRGRNEGVLGYTIVVG
DAEDDRRAPHPAEQRIAARWNIRDNGRAADKWLSEVVRWTWRVKLSTQIETDLMAQVREA
AETEAINVFAANLKDLLLLAPAGPRPTLGLDPGLRTGVKVAVIDGTGQVAGHGAIFPHAP
QNQWDRSIEQLAAWCREYKIELVAIGNGTASRETEKLVGDLSKRYPELKLARIVVSESGA
SVYSASEFASKELPDLDVTIRGAVSIARRLQDPLAELVKIEPKSIGVGQYQHDVSQVQLS
RSLDAVVEDCVNGVGVDLNTASAPLLARVSGLNQTIAQNIIEFRNQNGMFRNRKQLLKVT
RLGDRTFEQAAGFLRIAGGENPLDRSSVHPEAYGVVEAIARKNNREVGDIIGDSSFLRGL
NPQDYVTEQFGLPTIKDIISELEKPGRDPRPEFRFASFEEGVETLSDLKPGMVLEGSVTN
VTNFGAFVDIGVHQDGLVHISALSHTFVKDPREVVKAGDIVKVKVMDVDIPRKRIALTMR
MDDQPGEKNEGKPMAANRSGASRKGGNRNAGNGGSGQKSPQGAMAGALAQALASARKDS