Protein Info for PGA1_c21670 in Phaeobacter inhibens DSM 17395

Annotation: betaine aldehyde dehydrogenase BetB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01804: betaine-aldehyde dehydrogenase
  • amino acids 12 to 472 (461 residues), 701.8 bits, E=1.7e-215
• PF00171: Aldedh
  • amino acids 18 to 474 (457 residues), 573 bits, E=2.1e-176

Best Hits

Swiss-Prot: 69% identical to BETB_RHOS1: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)

KEGG orthology group: K00130, betaine-aldehyde dehydrogenase [EC: 1.2.1.8] (inferred from 89% identity to sit:TM1040_1883)

MetaCyc: 69% identical to betaine aldehyde dehydrogenase (Sinorhizobium meliloti Rm2011)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]

Predicted SEED Role

"Betaine aldehyde dehydrogenase (EC 1.2.1.8)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.2.1.8)

MetaCyc Pathways

• choline-O-sulfate degradation (3/3 steps found)
• choline degradation I (2/2 steps found)
• glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
• glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
• glycine betaine biosynthesis III (plants) (2/3 steps found)
• β-alanine biosynthesis I (1/2 steps found)
• β-alanine biosynthesis IV (1/2 steps found)
• choline degradation IV (2/4 steps found)
• dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
• dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.8

Use Curated BLAST to search for 1.2.1.8

Sequence Analysis Tools

See I7ENM8 at UniProt or InterPro

Protein Sequence (485 amino acids)

>PGA1_c21670 betaine aldehyde dehydrogenase BetB (Phaeobacter inhibens DSM 17395)
MTHPAQPKASHFINGEYVEDTAGTPIPVIYAATGEQIATVHAATPAIVEQALSTAKAAQK
AWARMTGTERGRILRRAADIMRERNHDLSVLETYDTGKPLQETLVADATSGADALEYFGG
LAASLTGEHIPLGEDWVYTKREALGLCVGIGAWNYPTQIACWKGAPALACGNSMVFKPSE
TTPLCALKVAEILIEAGAPAGVFNVVQGMGEVGGALVTDPRVDKVSLTGSVPTGKKVYAA
AAEGMKHVTMELGGKSPLIIFDDADIDNAVGGAINGNFYSSGQVCSNGTRVFVQKGIKEK
FLARLAERTGNAILGDPMDEATSFGPMVTENQMNIVLGYIEKGKEEGARLICGGRRADMD
GYFIEPTVFADVTDDMTIAREEIFGPVMSVLDFDTEEEVVARANDTEFGLSAGVFTKDFT
RAHRVIGNLEAGSCFINSYNDAPVEAPFGGVKASGVGRENSKEAIKHFSQVKSVYVRMGD
VEAAF