Protein Info for PGA1_c02180 in Phaeobacter inhibens DSM 17395

Annotation: dihydrolipoyl dehydrogenase LpdA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 473 PF01134: GIDA" amino acids 7 to 60 (54 residues), 19.7 bits, see alignment 1.4e-07 PF07992: Pyr_redox_2" amino acids 7 to 318 (312 residues), 203.9 bits, see alignment E=1.4e-63 PF13738: Pyr_redox_3" amino acids 123 to 295 (173 residues), 38.1 bits, see alignment E=3.9e-13 PF00070: Pyr_redox" amino acids 172 to 250 (79 residues), 55.8 bits, see alignment E=1.9e-18 PF02852: Pyr_redox_dim" amino acids 339 to 444 (106 residues), 86.2 bits, see alignment E=6.4e-28

Best Hits

KEGG orthology group: K00520, mercuric reductase [EC: 1.16.1.1] (inferred from 72% identity to rde:RD1_1464)

Predicted SEED Role

"Mercuric ion reductase (EC 1.16.1.1)" in subsystem Mercuric reductase or Mercury resistance operon (EC 1.16.1.1)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.16.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EVY0 at UniProt or InterPro

Protein Sequence (473 amino acids)

>PGA1_c02180 dihydrolipoyl dehydrogenase LpdA (Phaeobacter inhibens DSM 17395)
MHEITCDLLVIGAGSGGLSVAAGASQMGADVVLLEGHKMGGDCLNYGCVPSKSLLASAKV
AYGQAHASAYGVADQMPVVDYAAAKDHVQDVIATIAPVDSQERFEGFGVRVIRAYGRFVD
DRVVEAGEHRITARRIVIATGSSPLVPPIDGLADVPYFTNETLFDLRERPEHLLIIGGGP
IGMEMAQAHIRLGSKVTVIEGDRALGKDDPELASIVLDQLRGEGIEIAEGAQAETIASTE
GGGIRVTAKDGRVFDGSHLLMAVGRKANIDKLNLEAAGVETNRAGVVVDDSLRSSNRRVY
AIGDVAGGMQFTHVAGYHAGVIIRSILFGLPSKAKTNHIPWATYTAPELAQVGLTEAQAR
EKHGDRLEVARFDYHHNDRALAERKSKGLIKVMVVKGRPIGASVVGHQAGELVALWSMAI
ANNLKMSQVAGMVAPYPTISEVNKRVAGAYFSPRLFDSPMVKRVVQFVQRWLP