Protein Info for PGA1_c21540 in Phaeobacter inhibens DSM 17395

Annotation: propionyl-CoA carboxylase alpha chain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00289: Biotin_carb_N
  • amino acids 1 to 109 (109 residues), 153.1 bits, E=1.6e-48
• PF02786: CPSase_L_D2
  • amino acids 115 to 322 (208 residues), 272.4 bits, E=1.1e-84
• PF02222: ATP-grasp
  • amino acids 131 to 292 (162 residues), 33.5 bits, E=1.5e-11
• PF07478: Dala_Dala_lig_C
  • amino acids 141 to 291 (151 residues), 30.7 bits, E=1e-10
• PF02785: Biotin_carb_C
  • amino acids 336 to 463 (128 residues), 109.7 bits, E=3.6e-35
• PF18140: PCC_BT
  • amino acids 482 to 606 (125 residues), 135.4 bits, E=5.8e-43
• PF00364: Biotin_lipoyl
  • amino acids 617 to 679 (63 residues), 64.2 bits, E=3.5e-21

Best Hits

KEGG orthology group: K01965, propionyl-CoA carboxylase alpha chain [EC: 6.4.1.3] (inferred from 88% identity to sil:SPO1101)

Predicted SEED Role

"Propionyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.3)" in subsystem Propionyl-CoA to Succinyl-CoA Module (EC 6.4.1.3)

MetaCyc Pathways

• methylaspartate cycle (15/19 steps found)
• propanoyl CoA degradation I (3/3 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• 3-hydroxypropanoate cycle (9/13 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (11/18 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• mycolate biosynthesis (21/205 steps found)
• superpathway of mycolate biosynthesis (22/239 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.3

Use Curated BLAST to search for 6.4.1.3

Sequence Analysis Tools

See I7F0Q8 at UniProt or InterPro

Protein Sequence (681 amino acids)

>PGA1_c21540 propionyl-CoA carboxylase alpha chain (Phaeobacter inhibens DSM 17395)
MFEKILIANRGEIACRVIKTARKMGIKTVAIYSDADKQSLHVKMADEAVHIGPPPANQSY
IVIDKVMEAIRATGAQAVHPGYGFLSENAKFAEALAAEGVAFVGPPVGAIESMGDKITSK
KIAQEAGVSTVPGYMGLIADADEAVKISNEIGYPVMIKASAGGGGKGMRIAWSDAEAREG
FQSSKNEAANSFGDDRIFIEKFVTQPRHIEIQVLCDAHGNGIYLGERECSIQRRNQKVVE
EAPSPFLDEDTRRAMGEQAVALAKAVGYASAGTVEFIVDGDKNFYFLEMNTRLQVEHPVT
ELITGVDLVEQMIRIAGGEPLSITQNDVKLNGWAIENRLYAEDPYRGFLPSIGRLTRYRP
PAEVAAGPLHDSGKWQGDAPAGELAVRNDTGVFEGGEISMYYDPMIAKLCTWGPTRDAAI
AAMRDALDGFEVEGIGHNLPFLSAVMDHPIFIAGTMTTAFIEEQYPEGFNGVELPEQDLR
KIAAASAAMHRVAEIRRTRVSGRMDNHERKVGSDWVVTLQDVSFNVTVDADRDGSTVRFD
DGSALRVASDWTPGDQLARLTVGDDSLVVKVGKISGGFRIRSRGADLKVHVRTPRQAELA
KLMPEKIAPDTSKLLLCPMPGLVVKLEVEVGDEVQEGQALCTIEAMKMENILRAEKKGVV
SAINAAAGDSLAVDEVIMEFE