Protein Info for PGA1_c21510 in Phaeobacter inhibens DSM 17395

Annotation: methylmalonyl-CoA mutase BhbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00641: methylmalonyl-CoA mutase N-terminal domain
  • amino acids 26 to 546 (521 residues), 877 bits, E=3.4e-268
• PF01642: MM_CoA_mutase
  • amino acids 28 to 540 (513 residues), 846.7 bits, E=5.7e-259
• TIGR00640: methylmalonyl-CoA mutase C-terminal domain
  • amino acids 578 to 706 (129 residues), 196.8 bits, E=1.2e-62
• PF02310: B12-binding
  • amino acids 581 to 696 (116 residues), 70.3 bits, E=1.3e-23

Best Hits

Swiss-Prot: 73% identical to MUTB_RHIME: Methylmalonyl-CoA mutase (bhbA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01847, methylmalonyl-CoA mutase [EC: 5.4.99.2] (inferred from 93% identity to sil:SPO1105)

MetaCyc: 84% identical to methylmalonyl-CoA mutase (Cereibacter sphaeroides)
Methylmalonyl-CoA mutase. [EC: 5.4.99.2]

Predicted SEED Role

"Methylmalonyl-CoA mutase (EC 5.4.99.2)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 5.4.99.2)

MetaCyc Pathways

• methylaspartate cycle (15/19 steps found)
• propanoyl CoA degradation I (3/3 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• 3-hydroxypropanoate cycle (9/13 steps found)
• pyruvate fermentation to propanoate I (4/7 steps found)
• conversion of succinate to propanoate (1/3 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (11/18 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (7/13 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (7/14 steps found)
• L-glutamate degradation VIII (to propanoate) (4/11 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.99.2

Sequence Analysis Tools

See I7DS08 at UniProt or InterPro

Protein Sequence (707 amino acids)

>PGA1_c21510 methylmalonyl-CoA mutase BhbA (Phaeobacter inhibens DSM 17395)
MTTKTDDWRALAEKELRGRPLDALTWNTLEGIDVKPLYTEADTKDLPHMGTMPGFGPFTR
GVKATMYAGRPWTIRQYAGFSTAEESNAFYRRNLAAGQQGVSVAFDLATHRGYDSDHPRV
MGDVGKAGVAIDSVEDMKILFDGIPLDQVSVSMTMNGAVIPILASFIVAGEEQGHDKSLL
AGTIQNDILKEFMVRNTYIYPPEPSMRIISDIIEYTSNEMPKFNSISISGYHMQEAGANL
VQELAYTLADGREYVRAAMEAGMDVDKFAGRLSFFFAIGMNFFMEIAKLRAARTLWHRVM
TDFDAKNDRSKMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAI
ALPTDFSARIARNTQLVLQEETGVTNVVDPLAGSYYVESLTNELIEKAWALMEEVEEMGG
MTKAVASGMPKLRIEESAARRQAMIDRGEEVIVGVNKYRKEKEDPIDILDVDNVAVRDSQ
IARLETLRADRDSAACEAALDNLTRVAKEGGNLLAAAVEAARARASVGEISMAMEKEFGR
HSAEVKTLAGVYGAAYEGDEGFAAIQKSIEDFAEAEGRRPRLLVVKMGQDGHDRGAKVIA
TAFADIGFDVDVGPLFQTPDEAAQDAIDNDVHVVGISSQAAGHKTLAPQLVKALKEQGAE
DIIVICGGVIPQQDYQFLYDNGVKAIFGPGTNIPEAAQDILKLIRQS