Protein Info for HP15_2052 in Marinobacter adhaerens HP15

Annotation: exodeoxyribonuclease VII large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 462 PF13742: tRNA_anti_2" amino acids 21 to 114 (94 residues), 107.5 bits, see alignment E=5.2e-35 TIGR00237: exodeoxyribonuclease VII, large subunit" amino acids 22 to 344 (323 residues), 432.6 bits, see alignment E=7.9e-134 PF01336: tRNA_anti-codon" amino acids 41 to 115 (75 residues), 50 bits, see alignment E=3.5e-17 PF02601: Exonuc_VII_L" amino acids 137 to 449 (313 residues), 383.6 bits, see alignment E=1.4e-118

Best Hits

Swiss-Prot: 54% identical to EX7L_HAHCH: Exodeoxyribonuclease 7 large subunit (xseA) from Hahella chejuensis (strain KCTC 2396)

KEGG orthology group: K03601, exodeoxyribonuclease VII large subunit [EC: 3.1.11.6] (inferred from 73% identity to maq:Maqu_1729)

MetaCyc: 48% identical to exodeoxyribonuclease VII subunit XseA (Escherichia coli K-12 substr. MG1655)
Exodeoxyribonuclease VII. [EC: 3.1.11.6]

Predicted SEED Role

"Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)" in subsystem DNA repair, bacterial (EC 3.1.11.6)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.6

Use Curated BLAST to search for 3.1.11.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PRA7 at UniProt or InterPro

Protein Sequence (462 amino acids)

>HP15_2052 exodeoxyribonuclease VII large subunit (Marinobacter adhaerens HP15)
MYNDGSGPATPHLQDTRPRALSVSELNHQARHLLESSFMQVWVEGELSGLSRPSSGHWYF
SLKDRKCQVRCAMFRGMNQRIRTPPKEGDQVRIRGKVTLYENRGDFQIIVEHVEPAGLGA
LQQAFEELKRKLLAEGLFEQASKKPLPSLPRHIGVVTSPTGAAIHDILTVLARRCPAIPV
TLYPTAVQGKAATADIVRAIEAAQNHGVADVLIIGRGGGSLEDLWCFNEEAVARAIAACR
IPTVSAVGHEVDVTIADFVADLRAPTPSAAAEKISPDQSDWLKQLRDREFRLSNAMGLAL
KRLGTQLGHLSARLRDPRRELLEKAQRMDELELRLRKAIRQRLTTVGVRNDHLRQRLVMQ
SPHRQLSDSQDALRRVSERLVSVMQQDLKQRRDNLEHAAQTLNVVSPLATLGRGYSIVRD
NNGNILRDASNVNPGDTISARVARGEMTAKVTSVKSAEETGP