Protein Info for HP15_206 in Marinobacter adhaerens HP15

Annotation: Xaa-Pro dipeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 PF21216: PepQ_N" amino acids 13 to 152 (140 residues), 97.2 bits, see alignment E=9.5e-32 PF00557: Peptidase_M24" amino acids 165 to 420 (256 residues), 133.9 bits, see alignment E=6.9e-43

Best Hits

Swiss-Prot: 74% identical to PEPQ_MARHV: Xaa-Pro dipeptidase (pepQ) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K01271, Xaa-Pro dipeptidase [EC: 3.4.13.9] (inferred from 74% identity to maq:Maqu_0455)

Predicted SEED Role

"Xaa-Pro dipeptidase PepQ (EC 3.4.13.9)" (EC 3.4.13.9)

Isozymes

Compare fitness of predicted isozymes for: 3.4.13.9

Use Curated BLAST to search for 3.4.13.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PK39 at UniProt or InterPro

Protein Sequence (440 amino acids)

>HP15_206 Xaa-Pro dipeptidase (Marinobacter adhaerens HP15)
MAMPDDALLSLQTDHLKELQARYESALAEHGYDSLLIASGAAPYRYGDDQAWHFQGYGPF
LHWTGLAGREHCWLWIRAGHKPVLWLFEPVDFWHANSPLAEEPWRQFIEVRSSASPEAPL
LDDPESLAVIGDPALISNIPGEKNPEALLRDLDETRVCKTPYEIECLAQANRLALAGHAA
AREAFLVGESEFGINLAYQQATGQREAEAPYHSIIGLNEHAGTLHYQYYDTQPPGQTRSL
LIDAGVRFRGYCSDITRTTAGPEESHFAALIHGLDRLQVRLCDMVAPGVDYIDIHRKAHQ
GLAALLSATGLVTGLDDEGIVEKGITRVFFPHGIGHFLGVQVHDVAGKPTPPPDDAPFLR
LTRRLEPGMVVTIEPGLYFIPSLLDPLLEGELGQYLNRELIGRLRGCGGIRIEDNVVVTD
AGSRNLTGGCESRNTKVAQI