Protein Info for HP15_1980 in Marinobacter adhaerens HP15

Annotation: virulence-associated E family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 298 PF13662: Toprim_4" amino acids 206 to 275 (70 residues), 27.8 bits, see alignment E=2.5e-10 PF13362: Toprim_3" amino acids 206 to 283 (78 residues), 35.4 bits, see alignment E=1.2e-12

Best Hits

Predicted SEED Role

"DNA primase (EC 2.7.7.-)" in subsystem DNA-replication or Macromolecular synthesis operon (EC 2.7.7.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.-

Use Curated BLAST to search for 2.7.7.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PQM4 at UniProt or InterPro

Protein Sequence (298 amino acids)

>HP15_1980 virulence-associated E family protein (Marinobacter adhaerens HP15)
MDIDAVLTQMRDLGLLVDSIDTSGKLVRVPVTFPRADKGKKKSGWYVVHEFRLNSGGIGL
AGSFGNYKIDERRKVGMPAGSLTEEDRKEYQRRRKQAQEKARKEQEAAAKECREKAQRIW
SKLPVDGPSKYLAAKGVAPFGLRFSRGSVVVPVYKPVACDGPQLFALDLVSLQWISPEGE
KTFLTGTPKEGSFHWLTDIPEAECPVVIVEGYATGASVHMATGLPVAVAFDSGNLVPVAK
VLRQFFPTARICIAGDEDKETEERIGKNPGRLKAEEAANAVNGVWVVPDFAEAADGVD