Protein Info for PGA1_c19850 in Phaeobacter inhibens DSM 17395

Annotation: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 325 TIGR00557: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA" amino acids 9 to 323 (315 residues), 405.3 bits, see alignment E=1.1e-125 PF04166: PdxA" amino acids 51 to 319 (269 residues), 338.7 bits, see alignment E=1.6e-105

Best Hits

Swiss-Prot: 72% identical to PDXA_RUEST: 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA) from Ruegeria sp. (strain TM1040)

KEGG orthology group: K00097, 4-hydroxythreonine-4-phosphate dehydrogenase [EC: 1.1.1.262] (inferred from 76% identity to sil:SPO2457)

Predicted SEED Role

"4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.262)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.262

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F0A6 at UniProt or InterPro

Protein Sequence (325 amino acids)

>PGA1_c19850 4-hydroxythreonine-4-phosphate dehydrogenase PdxA (Phaeobacter inhibens DSM 17395)
MSRPARPLPIALSCGEPAGIGPELAVKAWQDLRDSCPFLWLGDPRHLPTGTDWQEIDNAA
EAVDVSASAMPVLRVDFAAPTVPGQLNPDNAAGVIRAIEAGVALVQSGEASALCTAPIHK
KALMDGAQFPFPGHTEFLAHLGNVQNVVMMLASPALRVVPATIHIALAEVPKALTADRLR
ATIEITAQGLRDQFGLAHPRIAIAGLNPHAGEEGAMGHEELDWMRTLIADMQGGAYTLSG
PHPADTMFHAAARARYDAAICMYHDQALIPIKTLDFDRGVNVTLGLPFIRTSPDHGTACD
IAGQGIANPSSLIEALRLAQSMACS