Protein Info for PGA1_c19750 in Phaeobacter inhibens DSM 17395

Annotation: nucleoside diphosphate kinase Ndk

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00334: NDK
  • amino acids 4 to 136 (133 residues), 183.9 bits, E=6.5e-59

Best Hits

Swiss-Prot: 93% identical to NDK_RUEPO: Nucleoside diphosphate kinase (ndk) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: K00940, nucleoside-diphosphate kinase [EC: 2.7.4.6] (inferred from 92% identity to sit:TM1040_0957)

MetaCyc: 60% identical to nucleoside diphosphate kinase (Escherichia coli K-12 substr. MG1655)
Nucleoside-diphosphate kinase. [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]

Predicted SEED Role

"Nucleoside diphosphate kinase (EC 2.7.4.6)" in subsystem Purine conversions (EC 2.7.4.6)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• ppGpp metabolism (6/6 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (8/9 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• CMP phosphorylation (2/2 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (5/7 steps found)
• superpathway of pyrimidine ribonucleosides salvage (7/10 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)
• dZTP biosynthesis (3/5 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.6

Sequence Analysis Tools

See I7F095 at UniProt or InterPro

Protein Sequence (140 amino acids)

>PGA1_c19750 nucleoside diphosphate kinase Ndk (Phaeobacter inhibens DSM 17395)
MALERTFSIIKPDATRRNLTGKINAKFEDAGLRIVAQKRIHLTKAQAGEFYAVHAERPFY
DELCEFMASAPIVAQVLEGENAIAKNREVMGATNPADAAAGTIRAEFAESVGENSVHGSD
APETAAVEIAYFFSGLELVG