Protein Info for HP15_194 in Marinobacter adhaerens HP15

Annotation: mercuric ion reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details TIGR02053: mercury(II) reductase" amino acids 8 to 468 (461 residues), 576.1 bits, see alignment E=3.1e-177 PF07992: Pyr_redox_2" amino acids 8 to 325 (318 residues), 226.9 bits, see alignment E=1.8e-70 PF00890: FAD_binding_2" amino acids 9 to 43 (35 residues), 22.9 bits, see alignment 2.3e-08 PF01134: GIDA" amino acids 9 to 124 (116 residues), 25.8 bits, see alignment E=2.9e-09 PF13738: Pyr_redox_3" amino acids 145 to 309 (165 residues), 43 bits, see alignment E=1.8e-14 PF00070: Pyr_redox" amino acids 180 to 250 (71 residues), 55.6 bits, see alignment E=3.2e-18 PF02852: Pyr_redox_dim" amino acids 344 to 450 (107 residues), 101.8 bits, see alignment E=1.2e-32

Best Hits

Swiss-Prot: 67% identical to MERA_ENTAG: Mercuric reductase (merA) from Enterobacter agglomerans

KEGG orthology group: K00520, mercuric reductase [EC: 1.16.1.1] (inferred from 94% identity to maq:Maqu_4010)

Predicted SEED Role

"Mercuric ion reductase (EC 1.16.1.1)" in subsystem Mercuric reductase or Mercury resistance operon (EC 1.16.1.1)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.16.1.1

Use Curated BLAST to search for 1.16.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PK27 at UniProt or InterPro

Protein Sequence (468 amino acids)

>HP15_194 mercuric ion reductase (Marinobacter adhaerens HP15)
MKNDQKLHIAVIGSGGAAMAAALKATERGARVTLIERGTVGGTCVNVGCVPSKIMIRAAH
IAHLRKESPFDAGISAAAPEVDRAKLLQQQLARVEELRDTKYEKILREHKDITVLNGEAR
FLDTNSLLVTLAEGGEKPVHFDRAFIGTGARPAEPPITGLADTPYLTSTSALTLDTGPKR
LIVIGAGFVALELAQAFARLGSKVTVLARSRVLSSEDPAIGEAIAGAFNREGIEVLSQTL
PSNVDYSDNEFIVETPAGTLRADQLLVATGRTPNTEALNLASIGVETSRDAIQVDEHLQT
TVPGIYAAGDCTNQPQFVYVAAAGGSRAAINMTEGEAKLDFSAMPGVMFTDPQVATVGLS
EAEAVARGYSVDTRLLDLENVPRALVNFDTQGFIKMVAERNSGRLLGVQIVAAEGGEIIQ
TAVMALRAGLTVQEIGDDLFPYLTMVEGFKLCAQTFTKDVKQLSCCAG