Protein Info for PGA1_c18880 in Phaeobacter inhibens DSM 17395

Annotation: heme exporter protein B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 218 transmembrane" amino acids 12 to 37 (26 residues), see Phobius details amino acids 44 to 64 (21 residues), see Phobius details amino acids 96 to 117 (22 residues), see Phobius details amino acids 123 to 149 (27 residues), see Phobius details amino acids 156 to 177 (22 residues), see Phobius details amino acids 191 to 213 (23 residues), see Phobius details PF03379: CcmB" amino acids 1 to 215 (215 residues), 288.9 bits, see alignment E=1e-90 TIGR01190: heme exporter protein CcmB" amino acids 4 to 214 (211 residues), 279.9 bits, see alignment E=6.6e-88

Best Hits

Swiss-Prot: 80% identical to CCMB_RHOCB: Heme exporter protein B (helB) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)

KEGG orthology group: K02194, heme exporter protein B (inferred from 90% identity to sil:SPO2316)

MetaCyc: 46% identical to cytochrome c maturation protein B (Escherichia coli K-12 substr. MG1655)
RXN-21408

Predicted SEED Role

"ABC transporter involved in cytochrome c biogenesis, CcmB subunit" in subsystem Biogenesis of c-type cytochromes

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E1G6 at UniProt or InterPro

Protein Sequence (218 amino acids)

>PGA1_c18880 heme exporter protein B (Phaeobacter inhibens DSM 17395)
MRALLLRDLRLTLRAGGGFGLGLAFFLIVTVLVPFSVGPQSELLGRIAPGVLWLGALLAC
LLSLDRLLALDWEDGTLDLMATAPLPLEAVVTIKALAHWITTSLPLVLAAPVLGVLLNLP
TAGFLWLVVSLLLGTPALSVIGTFGAALTVGLKRGGLLMSLLVLPLYVPTLIFGAEAARR
GAAGMAVETPLLMLAGISAATLALLPFASAAVLRVNLR