Protein Info for PGA1_c18870 in Phaeobacter inhibens DSM 17395

Annotation: heme exporter protein C

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 243 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 55 to 81 (27 residues), see Phobius details amino acids 93 to 113 (21 residues), see Phobius details amino acids 127 to 146 (20 residues), see Phobius details amino acids 156 to 175 (20 residues), see Phobius details amino acids 202 to 222 (21 residues), see Phobius details PF01578: Cytochrom_C_asm" amino acids 13 to 183 (171 residues), 132.9 bits, see alignment E=6.4e-43 TIGR01191: heme exporter protein CcmC" amino acids 43 to 227 (185 residues), 260 bits, see alignment E=6.2e-82

Best Hits

Swiss-Prot: 73% identical to CCMC_RHOCB: Heme exporter protein C (helC) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)

KEGG orthology group: K02195, heme exporter protein C (inferred from 88% identity to sit:TM1040_1001)

Predicted SEED Role

"Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE" in subsystem Biogenesis of c-type cytochromes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EMT4 at UniProt or InterPro

Protein Sequence (243 amino acids)

>PGA1_c18870 heme exporter protein C (Phaeobacter inhibens DSM 17395)
MSIWEYANPKKFLTTSERVMPALWVSAAVLCTVGLIWGFFFTPDDYRQGSTVKIIFLHVP
AALIAINAWFMMLVASLIWVVRRHHVSALAAKAAAPIGVVMTLIALITGALWGQPMWGTW
WEWDPRLTSFLVLFLFYLGYIALWEAIEDPDTAADLTSILCLVGSVFAVLSRYAVNFWNQ
GLHQGASLSLDKEENVADAFSNPLYVCMIGFGLLFLALVLYRTGTEIRARRMRALMLRER
MQA